About the Project
CB2 is expressed primarily in the immune system and CB2-targeted drugs are promising therapeutic leads in a wide range of disorders involving immune system dysregulation, including multiple sclerosis, autoimmune disorders, atherosclerosis, stroke and inflammatory bowel disease.
We are particularly interested in studying functional selectivity, wherein a single GPCR has the potential to mediate the activation or inactivation of diverse signalling pathways and each molecule that interacts with the receptor has the potential to induce a unique ‘fingerprint’ of signalling events within the cell. An emerging concept in functional selectivity is that of spatio-temporal modulation, and this project will characterise ligand function in this context by utilising cutting-edge spatially restricted signalling pathway biosensors.
This project will investigate these aspects of CB2 signalling and function from a variety of aspects, including investigating the influences of spatial and temporal signalling bias on CB2 function in human primary immune cells. As well, we collaborate with medicinal chemists who generate new cannabinoid compounds with potential for generating signalling and/or spatial bias which will be investigated and have potential to be developed into novel therapeutic leads.
Skills Taught (background / working knowledge on application advantageous)
• Mammalian cell culture and transfection
• GPCR signalling assays, e.g. cAMP, pERK, intracellular calcium, beta-arrestin, intracellular trafficking
• Biosensor assays utilising resonance energy transfer (RET) technologies
• Immune cell functional assays
• Molecular biology / cloning
An outstanding GPA/E from the suitable qualifying degree is a minimum requirement for consideration.
A background in GPCR Molecular Pharmacology and/or Immunology is strongly preferred.
Competitive scholarship funding is available. More information: View Website
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