This project aims to develop new synthetic methods that deliver increased efficiency and precision in the synthesis of spirocyclic sp3-rich molecules. Such spirocyclic scaffolds are of significant value in a medicinal chemistry setting as they offer enhanced three-dimensionality that can increase potency, selectivity and lead to an improved pharmacokinetic profile. To achieve these aims, this project will explore the discovery of new synthetic strategies that combine the use of transition metal-catalysis (e.g. site selective cobalt and rhodium C-H functionalisation) and photochemistry (using visible-light irradiation in combination with photoredox catalysts or energy transfer catalysts) to access unique reactive intermediates and harness their reactivity in new synthetic transformations.
Eligible only for Australian or New Zealand Citizens or Permanent Residents. The project would be suitable for anyone with a strong background in synthetic organic chemistry. Candidates should hold or expect to gain a first-class degree or and/or an appropriate Master’s level qualification (or their equivalent) and first author publication(s). Applicants whose first language is not English will be required to demonstrate proficiency in the English language (IELTS 6.5 or equivalent).
The project will be supervised by Dr Daniel Priebbenow (www.monash.edu/pharm/research/themes/medicinal-chemistry/priebbenow-group/home) in collaboration with other research teams at Monash University. The student will receive training in organic synthesis, photochemistry and flow chemistry. Transferable skills including scientific communication, time management, project management will also be developed through Faculty PhD training programmes, group meetings and conference attendance/presentations.
The successfully candidate will join a highly active research group of PhD students and researchers at the Monash Institute of Pharmaceutical Sciences in Parkville, Melbourne. The highly collaborative Institute comprises a range of chemistry- and biology-based research groups and is well equipped with synthesis and analytical equipment.
Please contact Dr Daniel Priebbenow (Email: firstname.lastname@example.org) for further information. Interested applicants (Eligible only for Australian or New Zealand Citizens or Permanent Residents) should provide details of their qualifications, including a CV, publications and a brief covering letter outlining their motivation and experience for the position before the 10th October 2022.