Proteins bind and recognise each other using large surface areas. This recognition process is vital for a variety of biological applications. Sensing and recognizing specific proteins is therefore important for a number of applications, including medicine, biology and chemistry.
One aim of this project will be the synthesis of large molecules called dendrimers. These are globular macromolecules that contain a large number of terminal groups, which can be modified with a variety of functional groups, either covalently or non-covalently. This aspect of the project will involve the synthesis f dendrimers and their functionalisation to generate systems that can be applied as selective protein ligands and sensors for use in purification and target specific drug delivery
We have also been studying the use of graphene oxide for similar applications. Graphene oxide is large flat sheet that can interact and bind aromatic and hydrophobic molecules (via pi-pi and hydrophobic interactions), Also, the surface and edges of graphene oxide contains pockets of oxygen containing functional groups that can be converted to other functional groups designed to interact with target molecules. This aspect of the project will involve the functionalisation of graphene oxide to generate systems that can be applied as protein ligands and sensors, and as target specific delivery systems for photodynamic therapy.
For more information, please contact Dr Twyman ([Email Address Removed]) and see Dr Lance J. Twyman | Chemistry | The University of Sheffield
Subject Area: synthetic chemistry, medicinal chemistry, supramolecular chemistry, drug delivery and macromolecules.
Click here to apply. Your application should be accompanied by a 1-page personal statement outlining your reasons for applying.
Funding
Applicants should have a scholarship or be self-funded.
Requirements: At least a 2:1 honours degree or an MSc in Chemistry, or a related subject.
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