New Methods to Access Enantioenriched Heterobicyclic Scaffolds

   Department of Pure and Applied Chemistry

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  Prof William Kerr, Dr David Lindsay  Applications accepted all year round  Funded PhD Project (UK Students Only)

About the Project

A fully-funded, industry-linked, PhD Studentship is available in the Department of Pure and Applied Chemistry at the University of Strathclyde, Glasgow. This will be under the collaborative supervision of Professor William J. Kerr and Dr David M. Lindsay. The position is expected to commence any time from now and up until October 2023, and is funded in collaboration with world-leading pharmaceutical company, GSK, for a duration of 4 years. 

The general interests of the Kerr and Lindsay laboratories cover a broad range of metal-mediated synthetic organic chemistry and, in particular, the development of new preparative techniques, the creation of asymmetric processes, and the use of these emerging methods in total synthesis programmes.

The available project will specifically explore new applications for chiral magnesium amide-mediated asymmetric deprotonation of prochiral ketones. Access to enantiomerically-enriched novel bicyclic substrates possessing enol phosphate motifs will allow transformation into chiral, sp3-rich heterobicyclic frameworks through an iterative cross-coupling-oxidation-heterocycle formation sequence, the rapid construction of a broad range of novel heterobicyclic scaffolds of potential pharmaceutical interest. As part of the overall programme of work, computationally-driven methods will inform catalyst design, direct reaction scope, and investigate reaction mechanism.

The successful applicant will join an extremely motivated and industrious research team. They will receive elevated levels of training in the areas of preparative chemistry, organometallic-based synthesis, reaction mechanism, computational methods, and the associated analytical/spectroscopic requirements.

 Applicants must have, or expect to obtain, a strong MChem (or equivalent) degree as a requirement of the funding. Additionally, the position is well suited to students with significant experience in Synthetic Organic Chemistry obtained either through industrial placement or as part of an MChem/MSci research project.

Please submit your application by e-mail to Dr Laura C. Paterson ([Email Address Removed]), which should include: 

• Cover letter, detailing your experience and motivation for PhD studies 

• CV with two referees details included 

• Full transcripts from your undergraduate degree

• Other pertinent information (e.g., publications, awards, and other distinctions)

Chemistry (6)

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