New types of modified mRNA bearing diverse substituents at nucleobases will be prepared by polymerase incorporation of modified nucleoside triphosphates and the influence of these non-natural substituents on interactions with proteins as well as on translation will be studied.
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Milisavljevič, N.; Perlíková, P.; Pohl, R.; Hocek, M.: "Enzymatic synthesis of base-modified RNA by T7 RNA polymerase. A systematic study and comparison of 5-substituted pyrimidine and 7-substituted 7-deazapurine nucleoside triphosphates as substrates" Org. Biomol. Chem. 2018, 16, 5800-5807.