New technologies for metabolic imaging of the retina

Whereas existing imaging techniques for imaging the retina (eg optical coherence tomography, scanning laser ophthalmoscopes) produce images of retinal structure, we will develop new imaging technologies for: enhanced imaging of retinal chromophores such as drusen that are important for diagnosis of eye disease; and for mapping of metabolism indicators, such as flavoproteins, which offer a convenient route to detection of a wide range of systemic diseases.

The student will develop a new capability and instrumentation for spectral fluorescence-lifetime imaging (FLIM) of the retina to underpin an identified need for enhanced chemical imaging of the retina, for the detection of systemic and retinal disease. Fluorescence imaging and FLIM imaging have been independently employed for retinal imaging, but without the spectral and lifetime imaging discrimination necessary for quantitative mapping. This relatively unexplored area is only recently made attractive by the availability of tuneable picosecond light sources and single-photon avalanche photodetectors. It is envisaged that this will result in a laboratory-prototype instrument with a flexible integration of these complementary modalities. A rigorous assessment and validation programme will culminate in demonstration of efficacy on humans.

The project is jointly financed by Optos and CENSIS. The PhD will be conducted within the Imaging Concepts Group, in the School of Physics at Glasgow University (https://www.gla.ac.uk/schools/physics/research/groups/imagingconcepts/) and will be expected to spend some at Optos learning about ophthalmoscope design.

The ideal student will have a background in physics, electronic engineering or a related discipline and have an interest in optics and its application to biomedical applications.

Potential applicants are very welcome to contact Prof Harvey for informal discussions about the post by email or telephone. Applications consisting of a CV and covering letter should be emailed to Prof Andy Harvey [Email Address Removed]. The starting date is nominally October 2019.