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New technologies for metabolic imaging of the retina

  • Full or part time
  • Application Deadline
    Applications accepted all year round
  • Funded PhD Project (European/UK Students Only)
    Funded PhD Project (European/UK Students Only)

Project Description

Retinal imaging systems are the dominant tools for screening and informing treatment for retinal disease. Whereas existing imaging modalities produce images of retinal structure, we will develop new imaging technologies for: enhanced imaging of retinal chromophores such as drusen that are important for diagnosis of eye disease; and for mapping of metabolism indicators, such as flavoproteins, which offer a convenient route to detection of a wide range of systemic diseases.

The student will develop a new capability and instrumentation for spectral fluorescence-lifetime imaging (FLIM) of the retina to underpin an identified need for enhanced chemical imaging of the retina, for the detection of systemic and retinal disease. Fluorescence imaging and FLIM imaging have been independently employed for retinal imaging, but without the spectral and lifetime imaging discrimination necessary for quantitative mapping. This relatively unexplored area is only recently made attractive by the availability of low-cost tuneable picosecond light sources and single-photon avalanche photodetectors. It is envisaged that this will result in a laboratory-prototype instrument with a flexible integration of these complementary modalities. A rigorous assessment and validation programme will culminate in demonstration of efficacy on humans.

The project is jointly financed by Optos and CENSIS. The PhD will be conducted within the Imaging Concepts Group, in the School of Physics at Glasgow University (https://www.gla.ac.uk/schools/physics/research/groups/imagingconcepts/) and will be expected to spend some at Optos learning about ophthalmoscope design.

The ideal student will have a background in physics, electronic engineering or a related discipline and have an interest in optics and its application to biomedical applications.

Potential applicants are very welcome to contact Prof Harvey for informal discussions about the post by email or telephone. Applications consisting of a CV and covering letter should be emailed to Prof Andy Harvey at the address below. The position will remain open until a suitable appointment is made - early applications are encouraged. The starting date is nominally October 2019.

Funding Notes

The studentship includes fees and a stipend for three and a half years at the standard EPSRC rate. The stipend rate is currently £15,009 per annum.

References

See https://www.gla.ac.uk/schools/physics/staff/andyharvey/#/publications,articles for recent publications. In particular see the following publications http://eprints.gla.ac.uk/144297/, http://eprints.gla.ac.uk/149691/ and http://eprints.gla.ac.uk/159073/

How good is research at University of Glasgow in Physics?

FTE Category A staff submitted: 44.90

Research output data provided by the Research Excellence Framework (REF)

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