Next generation RNA genotype-phenotype mapping
This is one of several projects available on an MRC funded 4-year multi-disciplinary PhD programme in Human Genetics, Genomics and Disease at the MRC Human Genetics Unit (HGU), part of the Institute of Genetics and Molecular Medicine (IGMM) at the University of Edinburgh.
Genome sequencing has become relatively cheap, and close to a million people have had their genome sequenced. To interpret this massive amount of information, our lab develops efficient methods for measuring and predicting the effects of genetic variation. We synthesize large collections of mutated genes, and develop high-throughput assays to measure the effects of mutations on molecular and cellular phenotypes, such as protein and RNA abundance, protein-RNA interactions, and fitness (Puchta et al., Science, 2016). We use a variety of experimental techniques, including gene synthesis, next-generation sequencing, microarrays, and automated microscopy, and experimental systems including bacteria, yeast, and mammalian cells.
For further information on how to apply for this project, please visit: https://www.ed.ac.uk/mrc-human-genetics-unit/graduate-research-and-training/mrc-four-year-phd-programme-human-genetics-genomic
For full funding (fees and stipend) students must be UK or EU citizens who have been resident in the UK for 3 years prior to commencement.
However, EU students with quantitative or multidisciplinary skills are eligible for full funding.