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Normal and malignant blood stem cell biology


Project Description

One of the simplest and most provocative concepts in all of stem cell biology is how a single stem cell can give rise to any of the highly specialised cell types of a given tissue while also having the capacity to make a new equally potent stem cell. At a population level, this decision-making process must exist in a tightly regulated balance in order to avoid tissue degeneration (too few stem cells) or progression to cancer (too many stem cells). Our lab explores the biology of adult blood stem cells and the process by which single blood stem cells are subverted to drive blood cancers such as leukaemia.

Our research is highly inter-disciplinary with three major themes:

1) Understanding the molecular regulators of normal blood stem cells
2) Clonal evolution of cancers from single cells
3) Physical and Mechanical Biology

Funding Notes

This is a self-funded project. Applicants need to have adequate funds to meet the costs of a self-funded research project including tuition fees and living expenses for the duration of the research programme. Please see information on tuition fee costs, living expenses and funding opportunities.

References

Applications are welcome for either for a 1-year MSc by Research or for a 3-year PhD.

How good is research at University of York in Biological Sciences?

FTE Category A staff submitted: 44.37

Research output data provided by the Research Excellence Framework (REF)

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