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Novel autophagy pathways for the control of influenza virus infection (WILEMANQ20DTP)

   Graduate Programme

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  Prof T Wileman  No more applications being accepted  Competition Funded PhD Project (European/UK Students Only)

About the Project

The recent outbreaks of avian influenza and the threat of a human influenza pandemic has highlighted the need to understand prevention and control of this virus by developing effective antiviral therapies. We have recently shown that influenza virus activates a novel autophagy pathway called LC3-associated phagoytosis (LAP). We have developed a unique animal model defective in this pathway, and this project will investigate host innate immune responses after this pathway has been compromised. Aberrant host defence leading to inflammatory disease may account for some of the pathological changes seen in this disease. Respiratory virus infections are of global significance to both the human and animal populations and this is an excellent opportunity to become involved an important area of human and veterinary interest. At the Quadram Institute, you will have access modern fully equipped laboratories with state of the art facilities of confocal microscopes, and in vivo imaging techniques. There is a large community of PGR students around Norwich Research Park and a wide number of opportunities for personal and professional development.

This project has been shortlisted for funding by the Norwich Biosciences Doctoral Training Partnership (NRPDTP). Shortlisted applicants will be interviewed as part of the studentship competition. Candidates will be interviewed on either the 7th, 8th or 9th January 2020.

The NRP DTP offers postgraduates the opportunity to undertake a 4-year research project whilst enhancing professional development and research skills through a comprehensive training programme. You will join a vibrant community of world-leading researchers. All NRPDTP students undertake a three-month professional internship (PIPS) during their study. The internship offers exciting and invaluable work experience designed to enhance professional development. Full support and advice will be provided by our Professional Internship team. Students with, or expecting to attain, at least an upper second-class honours degree, or equivalent, are invited to apply.

For further information and to apply, please visit our website:

Funding Notes

For funding eligibility guidance, please visit our website: Full Studentships cover a stipend (2019/0 rate: £15,009pa), research costs and tuition fees at UK/EU rate and are available to UK and EU students who meet the UK residency requirements.

Students from EU countries who do not meet the UK residency requirements may be eligible for a fees-only award. Students in receipt of a fees-only award will be eligible for a maintenance stipend awarded by the NRPDTP Bioscience Doctoral Scholarships. To be eligible students must meet the EU residency requirements.
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