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  Novel avenues in inflammation, vascular and bone research


   Institute of Inflammation and Ageing

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  Dr H McGettrick  Applications accepted all year round  Self-Funded PhD Students Only

About the Project

We are seeking talented, motivated students with a passion for research in musculoskeletal ageing and immune-mediated chronic inflammatory diseases (e.g., rheumatoid arthritis, obesity, cardiovascular disease) to join the Inflammation, Vascular and Bone team (IVB) led by Dr Helen McGettrick (https://www.birmingham.ac.uk/staff/profiles/inflammation-ageing/mcgettrick-helen.aspx).

Applicants should have a first or upper second-class degree in a relevant scientific discipline, and who are self-funded or have typically applied for, or secured funding for their studies from their government, employer or associated charitable organisations.

RESEARCH IN INFLAMMATION, VASCULAR AND BONE TEAM

The IVB team is part of the wider Rheumatology Research Group within the Institute of Inflammation and Ageing at the University of Birmingham. We are interested in identifying the endogenous regulatory pathways that control the normal processes of inflammation and tissue repair and how these go wrong with age, injury and during immune mediated inflammatory diseases.

Broadly speaking we have three main areas of interest:

• factors affecting leukocyte entry into tissue, movement through tissue and their subsequent exit from tissue;

• regulation of tissue and bone homeostasis and repair mechanisms;

• endothelial phenotypes in health, disease and different tissue beds;

We have ongoing projects examining:

• the ability of PEPITEM to regulate stromal cell function in health, old age and bone related diseases.

• the shared mechanisms of pathology in old age and immune-mediated inflammatory diseases, focusing on changes in leukocyte phenotypes and function;

• the regulation of leukocyte trafficking in health, with age and in arthritis, obesity, and inflammatory bowel disease

• how mesenchymal stromal cells influence endothelial responses and leukocyte recruitment;

We combine imaging novel in vitro, multi-cellular static and flow-based culture systems incorporating primary human cells (from healthy individuals or patients), with systems biology approaches to large omics datasets (e.g., RNAseq, metabolomic or proteomic data) and murine models of acute or persistent inflammation.

PhD projects, using these approaches, answering translationally relevant research questions are available to self-funded or scholarship-funded graduates interested in joining IVB.

APPLICATION ROUTES

Self-funded or scholarship-funded graduates interested in joining IVB can select one of 3 different routes for undertaking a PhD in the field of Inflammation and Ageing.

Applicants with research experience and/or Master’s degree should apply directly to the Institute of Inflammation and Ageing for either a 3 or 4 year full-time PhD – https://www.birmingham.ac.uk/postgraduate/courses/research/med/inflammation-ageing.aspx. This route requires applicants to submit a drafted research proposal.

Applicants seeking additional research experience or who have yet to complete a Master’s degree should apply to the 4 year Integrated Doctoral Training Programme in Life Sciences for Health, which combined a MRes and PhD – https://www.birmingham.ac.uk/postgraduate/pgr/idtp/index.aspx.

Applicants will need to submit the following documentation during the application process.

• Detailed CV, including your nationality and country of birth;

• Covering letter highlighting your research experience/capabilities and why you wish to undertake a PhD in the team;

• Names and addresses of two referees;

• Copies of your degree certificates with transcripts written in English;

• Evidence of your proficiency in the English language, if applicable.

• Evidence of scholarship application/funding or independent funding.

ADDITIONAL INFORMATION

For additional information on postgraduate studying at University of Birmingham please click - https://www.birmingham.ac.uk/study/postgraduate

For additional information on research at the College of Medical and Dental Sciences please click – https://www.birmingham.ac.uk/research/activity/mds/index.aspx

For additional information on research in the Institute of Inflammation and Ageing please click – https://www.birmingham.ac.uk/research/inflammation-ageing/index.aspx

For additional information on research within the Rheumatology Research Group please click - https://www.birmingham.ac.uk/research/inflammation-ageing/research/rheumatology-research-group/index.aspx

Biological Sciences (4) Materials Science (24) Medicine (26)

Funding Notes

Applicants are invited from self-funded or scholarship-funded graduates ONLY.
Applicants will have typically applied for, or secured funding for their studies from their government, employer or associated charitable organisations.
Overseas graduates require IELTs of 6.5 overall.
University of Birmingham offers pre-sessional English Language courses through the Birmingham International Academy – https://www.birmingham.ac.uk/international/bia/presessional/index.aspx
Applying directly to the Institute of Inflammation and Ageing for either a 3 or 4 year full-time PhD – https://www.birmingham.ac.uk/postgraduate/courses/research/med/inflammation-ageing.aspx.
Applying to the 4 year Integrated Doctoral Training Programme in Life Sciences for Health, which combined a MRes and PhD – https://www.birmingham.ac.uk/postgraduate/pgr/idtp/index.aspx.

References

https://pubmed.ncbi.nlm.nih.gov/?term=helen+mcgettrick&sort=pubdate

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