Novel bone-targeted therapy for multiple myeloma at University of Sheffield on FindAPhD.com

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Dr Michelle Lawson, Dr A Chantry Applications accepted all year round

About the Project

Myeloma remains an incurable cancer despite improvements in survival outcomes over the last few years, due to the development of better therapies. However, these therapies are often not suitable for frail patients due to significant toxicities. Niclosamide has been identified to have significant anti-myeloma effects in vitro. However, adverse effects have been observed using niclosamide in preclinical models of myeloma and in cancer patients. Therefore, we have conjugated niclosamide to 4 different bone-seeking bisphosphonate vectors and observed no adverse effects in vivo. Therefore, we now wish to determine the most effective anti-myeloma niclosamide vector in vivo, conduct combination studies to determine the most effective anti-myeloma treatment in vivo and determine the mechanism of action.

The Sheffield Myeloma Research Team seek a highly motivated individual with evidence of critical thinking. Experience in tumour or bone biology would be advantageous.

For further details please contact Dr Lawson ([Email Address Removed], http://www.sheffield.ac.uk/oncology-metabolism/staff/lawson)

Funding Notes

This project is open to self-funded students only.

Entry Requirements:
Candidates must have a first or upper second class honors degree or significant research experience. An MSc and experience in bone cancer would be advantageous

References

Enquiries:
Interested candidates should in the first instance contact Dr Lawson, m.a.lawson@sheffield.ac.uk

How to apply:
Please complete a University Postgraduate Research Application form available here: www.shef.ac.uk/postgraduate/research/apply

Please clearly state the prospective main supervisor in the respective box and select Oncology and Metabolism as the department.

Where will I study?

University of Sheffield

Our University has a reputation for world-class teaching and research excellence across a variety of disciplines. At Sheffield, you’re welcomed into a diverse, supportive community of scholars from all over the world.

Novel bone-targeted therapy for multiple myeloma

University of Sheffield Department of Oncology and Metabolism