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Novel bone-targeted therapy for treatment against dormant myeloma cells


Project Description

Multiple myeloma is a cancer of differentiated B-lymphocytes (plasma cells) that grow in the bone marrow. Despite the development and use of more effective drugs in the treatment of myeloma it remains an incurable disease, given that current treatment regimens are not able to eradicate all tumour cells. Residual disease is likely to be due to the existence of dormant myeloma cells and their protective interactions with the bone marrow stroma. Therefore, in this project we aim to develop novel bone-targeted anti-myeloma therapies to enhance their delivery to the tumour site and increase their efficacy against residual disease.

Funding Notes

Funding:
This project is open to self funded candidates who can cover: University Fees, Stipend and enhancements costs (lab consumables & conference travel, publications costs etc)

Entry Requirements:
Candidates must have a first or upper second class honors degree or significant research experience. In addition, candidates must be self-motivated, have the ability to think independently, use own initiative, have good communications skills and be well-organised including good time management. Experience in cancer biology, including cell culture and in vivo studies would be desirable but not essential.

Proposed start date: 1/10/2020

References

Enquiries:
Interested candidates should in the first instance contact (Dr Lawson, [email protected])


How to apply:
Please complete a University Postgraduate Research Application form available here: www.shef.ac.uk/postgraduate/research/apply

Please clearly state the prospective main supervisor in the respective box and select "Oncology & Metabolism" as the department.

Related Subjects

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