About the Project
The Wagner group has a long-standing track record in glycosyltransferase inhibitor development, including the discovery of a novel class of allosteric inhibitors (Nat Chem Biol 2010; J Med Chem 2012, J Biol Chem 2013, J Biol Chem 2015), and drug-like covalent inhibitors (Bioorg Med Chem 2017, Bioorg Med Chem 2018).
Building on this previous work, you will in this project apply the latest inhibitor design concepts in medicinal chemistry to develop novel glycosyltransferase inhibitors with suitable properties for applications in cell culture and whole organisms. You will also evaluate your inhibitor candidates in biochemical assays and, in collaboration with internal and external partners, advanced biological systems, e.g., for antibody engineering and antibacterial drug discovery.
The project will provide extensive multidisciplinary training at the chemistry/biology interface and is ideally suited for a student with a strong background in organic synthesis, who wants to significantly expand their experimental skill set.
Important, applicants must fulfil the eligibility criteria set out by the Department for the Economy which can be found at this link: https://www.nidirect.gov.uk/articles/department-economy-studentships
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