The correct spatiotemporal regulation of genetic programmes is critical for the development and function of complex organisms. The majority of vertebrate genome sequence is non-coding and includes many cis-regulatory elements (CREs) such as enhancers that control gene activity in a cell and tissue specific manner. The ability to accurately predict enhancer elements will provide a better understanding of the genetic control of cellular regulation as well as give insights into disease mechanisms.
This bioinformatics-based project will use next-generation sequencing data from gene expression and chromatin accessibility assays to develop a new computational tool to predict enhancer sequences across vertebrate genomes. The student will apply their method to new datasets generated at UEA in the Münsterberg and Wheeler labs and novel enhancer predictions will be experimentally validated.
The student will work closely with computational biologists and experimentalists in a collaborative, interdisciplinary environment. The project will be computational but there would be an opportunity to conduct some experimental validation work in the Münsterberg lab if the student wishes to do so.
This project would be suitable for graduates with a biology background who would like to specialise in bioinformatics or for computer science graduates with an interest in biology. The supervisory team and their research groups will provide appropriate support and training tailored to the background of the student.
The Norwich Research Park Biosciences Doctoral Training Partnership (NRPDTP) is open to UK and international candidates for entry October 2022 and offers postgraduates the opportunity to undertake a 4-year PhD research project whilst enhancing professional development and research skills through a comprehensive training programme. You will join a vibrant community of world-leading researchers. All NRPDTP students undertake a three-month professional internship placement (PIPS) during their study. The placement offers exciting and invaluable work experience designed to enhance professional development. Full support and advice will be provided by our Professional Internship team. Students with, or expecting to attain, at least an upper second class honours degree, or equivalent, are invited to apply.
This project has been shortlisted for funding by the NRPDTP programme. Shortlisted applicants will be interviewed on Tuesday 25th January, Wednesday 26th January and Thursday 27th January 2022.
Visit our website for further information on eligibility and how to apply: https://biodtp.norwichresearchpark.ac.uk/
Our partners value diverse and inclusive work environments that are positive and supportive. Students are selected for admission without regard to gender, marital or civil partnership status, disability, race, nationality, ethnic origin, religion or belief, sexual orientation, age or social background.
For more information on the supervisor for this project, please visit the UEA website www.uea.ac.uk
The start date is 01 October 2022
Entry requirements: At least UK equivalence Bachelors (Honours) 2:1 or UK equivalence Master's degree. English Language requirement (Faculty of Science equivalent: IELTS 6.5 overall, 6 in each category).
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