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Novel molecular mechanisms and therapeutic avenues in DNA damage-induced neurological disease


   School of Life Sciences

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  Prof K Caldecott  No more applications being accepted  Funded PhD Project (UK Students Only)

About the Project

Genetic defects in the repair of DNA single-strand breaks result in human hereditary diseases that span a spectrum of neuropathology from progressive neurodegeneration in the mildest diseases to neurodevelopmental defects and seizures in the most severe. Recently, we identified a novel molecular mechanism that underpins such diseases, in which ‘programmed’ DNA breakage in gene enhancers and/or hyperactivity of the SSB sensor protein PARP1 disrupts the expression of genes critical for normal neural function. This project will extend and exploit these and other exciting recent discoveries using a combination of molecular, cellular, and neurophysiological techniques that include CRISPR-Cas9 gene editing in human cells, iPSC-derived human neurons, and ex vivo/in vivo mouse models of DNA break-induced synaptic dysfunction.

How to apply:

Please submit a formal application using the online system at www.sussex.ac.uk/study/phd/apply attaching a CV, degree transcripts and certificates, statement of interest and two academic references.

On the application system select Programme of Study – Genome Stability PhD. Please ensure you state the project title under funding and include the proposed supervisor’s name where required.

For enquiries about the project, contact supervisor: [Email Address Removed]


Funding Notes

This School-funded position covers Home tuition fees and a stipend at standard UKRI rates for 3.5 years. Applicants with overseas fee status will need to fund the difference between Home and International tuition fees.
Ideal candidates will have a strong background in cell and molecular biology/neuroscience. Eligible applicants will hold a 2:1 BSc or above in a relevant subject. Candidates for whom English is not their first language will require an IELTS score of 6.5 overall, with not less than 6.0 in any section.

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