Novel MRI methods for assessment of fluid flows in the brain

Magnetic resonance imaging (MRI) has evolved from an anatomical imaging modality to the most versatile method for measuring brain physiology and microstructure in-vivo. Being able to non-invasively detect these properties is important for understanding disease processes (when and where they happen), and for developing drug treatments to modify these properties in the presence of disease.

It is the job of MRI physicists to design new sequences that can probe important aspects of brain physiology with high accuracy and precision. Our lab is interested in developing methods to probe fluid movement (convective and diffusive) within and between cellular and vascular compartments. In the healthy brain, fluid movements are tightly regulated, but can become disturbed in a range of disease states such as dementia, stroke, and cancer1-4. In this PhD project, the student will design novel MRI sequences to probe and measure different types of fluid flow (e.g. circulatory, glymphatic) in the brain.

Throughout the PhD the student will gain training in MRI physics, neuroscience, computer programming, and compartmental and kinetic modelling. They will join our highly multidisciplinary team of scientists working on MRI physics and neurodegeneration research, and play an active role in our neuroimaging seminar series and student activities.

Entry Requirements

Candidates are expected to hold (or be about to obtain) a minimum upper second class honours degree (or equivalent) in a related area/subject. Candidates with previous laboratory experience, particularly in cell culture and molecular biology, are particularly encouraged to apply.

How To Apply

For information on how to apply for this project, please visit the Faculty of Biology, Medicine and Health Doctoral Academy website (https://www.bmh.manchester.ac.uk/study/research/apply/). Informal enquiries may be made directly to the primary supervisor. On the online application form select PhD Genetics

For international students, we also offer a unique 4 year PhD programme that gives you the opportunity to undertake an accredited Teaching Certificate whilst carrying out an independent research project across a range of biological, medical and health sciences

Equality, Diversity and Inclusion

Equality, diversity and inclusion is fundamental to the success of The University of Manchester, and is at the heart of all of our activities. The full Equality, diversity and inclusion statement can be found on the website https://www.bmh.manchester.ac.uk/study/research/apply/equality-diversity-inclusion/”

For international students we also offer a unique 4 year PhD programme that gives you the opportunity to undertake an accredited Teaching Certificate whilst carrying out an independent research project across a range of biological, medical and health sciences. For more information please visit http://www.internationalphd.manchester.ac.uk