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Novel niclosamide-bisphosphonate vectors as bone-targeted therapy for multiple myeloma


Department of Oncology and Metabolism

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Dr Michelle Lawson , Dr A Chantry No more applications being accepted Self-Funded PhD Students Only

About the Project

Myeloma remains an incurable cancer despite improvements in survival outcomes over the last few years, due to the development of better therapies. However, these therapies are often not suitable for frail patients due to significant toxicities. Niclosamide has been identified to have significant anti-myeloma effects in vitro. However, adverse effects have been observed using niclosamide in preclinical models of myeloma and in cancer patients. Therefore, we have conjugated niclosamide to a bone-seeking bisphosphonate vector and now wish to assess its effects in vivo in a model of myeloma.

Funding Notes

Funding:
This project is open to self funded candidates who can cover: University Fees, Stipend and enhancements costs (lab consumables & conference travel, publications costs etc)

Entry Requirements:
Candidates must have a first or upper second class honors degree or significant research experience. In addition, candidates must be self-motivated, have the ability to think independently, use own initiative, have good communications skills and be well-organised including good time management. Experience in cancer biology, including cell culture and in vivo studies would be desirable but not essential.



References

Enquiries:
Interested candidates should in the first instance contact (Dr Lawson, m.a.lawson@sheffield.ac.uk)

How to apply:
Please complete a University Postgraduate Research Application form available here: www.shef.ac.uk/postgraduate/research/apply

Please clearly state the prospective main supervisor in the respective box and select "Oncology & Metabolism" as the department.


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