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  Novel stochastic modelling of molecular motors and implications for cardiac function/disease


   Faculty of Engineering, Environment & Computing

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  Prof E Kim  No more applications being accepted  Funded PhD Project (Students Worldwide)

About the Project

Coventry University (CU) is inviting applications from ambitious and self-motivated candidate for a fully-funded PhD studentship. 

With ever improved high-resolution data, fluctuations have emerged to be universal, playing a crucial role in many disciplines. Whilst large fluctuations only occur rarely, they can have a significant impact as, for example, with tornados or large stochastic events in biological systems. These large fluctuations are one of the important characteristics of non-equilibrium systems.

 

This project aims to investigate novel non-equilibrium phenomena at small (nano)-scales (e.g. molecular motors, Brownian ratchets, etc.) using statistical theory. Molecular motors are proteins of the order of 1-100 nano-metres that produce force and mechanical work by converting chemical energy in a noisy environment. They have superior efficiency compared with man-made motors, providing promising emerging nanotechnology that can be harnessed to address some of the world’s most critical development problems in Sustainable Well-being, Health and Energy.

An important example of molecular motors is myosin in cardiac muscles, which collectively provides the heart’s pumping power at the organ level. We aim to develop a novel stochastic theory of molecular motors and to investigate implications for cardiac function/disease. This project will involve learning theory and methods and as well as undertaking computer simulations.

The Supervisory team includes Prof E. Kim at the Centre for Fluid and Complex Systems (https://pureportal.coventry.ac.uk/en/persons/e-j-kim) and Prof D. Foster (https://pureportal.coventry.ac.uk/en/persons/damien-foster) at the Centre for Data Science at Coventry University.

Training and Development

The successful candidate will receive comprehensive research training including technical, personal and professional skills.

All researchers at Coventry University (from PhD to Professor) are part of the Doctoral College and Centre for Research Capability and Development, which provides support with high-quality training and career development activities. 

Entry criteria for applicants to PHD 

  • A minimum of a 2:1 first degree in a relevant discipline/subject area with a minimum 60% mark in the project element or equivalent with a minimum 60% overall module average. 

PLUS 

the potential to engage in innovative research and to complete the PhD within a 3.5 years

  • a minimum of English language proficiency (IELTS overall minimum score of 7.0 with a minimum of 6.5 in each component)

Eligibility:

UK/EU/International graduates with the required entry requirements

Duration:

Full-time – between three and three and a half years fixed term

For further details see: https://www.coventry.ac.uk/research/research-students/making-an-application/

How to apply

To find out more about the project please contact Professor Eun-Jin Kim

To apply on line please visit: https://pgrplus.coventry.ac.uk/

All applications require full supporting documentation, and a covering letter – plus one of the following:

For pre-determined (named) projects an up to 2000-word supporting statement is required showing how the applicant’s expertise and interests are relevant to the project.

Engineering (12) Mathematics (25) Physics (29)

Funding Notes

Bursary plus tuition fees (UK/EU/International)

This is a fully-funded studentship including full tuition fees (UK/EU/International) plus stipend (based upon the applicable UKRI rate at the point of the award) and additional allowances.