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Novel Strategies to Improve Yeast as an Expression Platform

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  • Full or part time
    Prof N Bryant
    Prof R J White
  • Application Deadline
    No more applications being accepted
  • Funded PhD Project (European/UK Students Only)
    Funded PhD Project (European/UK Students Only)

Project Description

Pichia pastoris (reclassified as Komagataella pastoris), is an established protein expression platform in the biopharmaceutical industry. It is valued for the availability of powerful and tightly regulated promoters, for its growth to very high densities and for its ability to secrete gram amounts of recombinant protein per litre of culture. Nevertheless, there is potential for improvement, especially as some proteins of interest are difficult to express in this system. This project seeks to develop novel strategies aimed at improving product quality and titre. It is a response to a challenge from Fujifilm Diosynth Biotechnologies (FDB) to improve their Pichia expression system, part of their broad range of capabilities enabling contract work to be performed from gene to final recombinant protein bulk drug substance. It will be encompassed within the Centre of Excellence in Bioprocessing 2.0, a new partnership between the Universities of Edinburgh, Manchester and York, the IBioIC and FDB. This is a rolling series of collaborative interdisciplinary research projects to address challenges in the manufacture of biologics.

Funding Notes

This studentship is part of the IBiolC Collaborative Training Partnership (CTP) in collaboration with Fujifilm Diosynth Biotechnologies (FDBK). It is fully-funded for 4 years and covers a tax-free student stipend (currently £15000 per year but increases annually in line with inflation), tuition fees at UK/EU rate and research costs The studentship includes a mandatory industry placement (minimum 3 months) hosted by the industrial partner (FDBK). All costs (e.g. travel, accommodation, lab costs) associated with the placement will be met by FDBK.

References

ENTRY REQUIREMENTS: Students with, or expecting to gain, at least an upper second class honours degree, or equivalent, are invited to apply. The interdisciplinary nature of this programme means that we welcome applications from students with backgrounds in any biological, chemical, and/or physical science, or students with mathematical backgrounds who are interested in using their skills in addressing biological questions.

Candidates invited for interview will be asked to give a 10-minute presentation on a piece of research they have carried out.

START DATE: 1st October 2020:

Related Subjects

How good is research at University of York in Biological Sciences?

FTE Category A staff submitted: 44.37

Research output data provided by the Research Excellence Framework (REF)

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