The aim of the project is to develop new highly effective anti-tubercular agents. Previously, it has been established that terpenes isolated from marine organisms possess a number of important antibacterial properties. It was revealed that the diterpene erogorgiaene exhibits a promising antimycobacterial activity, including the activity against the strains resistant to known antibacterial drugs. Our preliminary studies have demonstrated that the mechanism of action of erogorgianene on mycobacteria is fundamentally different from that of the existing medicinal drugs used in clinical practice. Therefore, the project will involve development of new synthetic routes towards analogues of the active substances accompanied by screening of the new compounds for antibacterial activity.
Links to find out more
For recent publication is this area, see: Incerti-Pradillos, C. A.; Kabeshov, M. A.; O’Hora, P. S.; Shipilovskikh, S. A.; Rubtsov, A. E.; Drobkova, V. A.; Balandina, S. Y.; Malkov, A. V. Asymmetric Total Synthesis of (–)-Erogorgiaene and Its C11 Epimer and Investigation of Their Antimycobacterial Activity. Chem. Eur. J. 2016, 22, 14390-14396.
[Entry requirements]] Applicants should have, or expect to achieve, at least a 2:1 Honours degree (or equivalent) in Chemistry.
A relevant Master's degree and / or experience in one or more of the following will be an advantage: Synthesis of natural products
How to apply
All applications should be made online. Under programme name select School of Science. Please quote reference number: CM/AM-Un1/2019