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Novel synthetic approaches to antimicrobial natural products and investigations of their bioactivity


   Department of Chemistry

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  Prof A Malkov  No more applications being accepted  Self-Funded PhD Students Only

About the Project

The aim of the project is to develop new highly effective anti-tubercular agents. Previously, it has been established that terpenes isolated from marine organisms possess a number of important antibacterial properties. It was revealed that the diterpene erogorgiaene exhibits a promising antimycobacterial activity, including the activity against the strains resistant to known antibacterial drugs.

Our preliminary studies have demonstrated that the mechanism of action of erogorgianene on mycobacteria is fundamentally different from that of the existing medicinal drugs used in clinical practice. Therefore, the project will involve development of new synthetic routes towards analogues of the active substances accompanied by screening of the new compounds for antibacterial activity

Entry requirements
A relevant master's degree. Experience in one or more of the following will be an advantage: synthesis of natural products, synthetic methodology development.

Applicants must meet the minimum English language requirements. Further details are available on the International website: https://www.lboro.ac.uk/international/apply/english-language-requirements/

How to apply
All applications should be made online: https://www.lboro.ac.uk/study/postgraduate/apply/research-applications/ Under school/department name, select 'Chemistry'. Please quote reference CM/AM-Un1/2021.

The deadline for applications is 30 September 2021.

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