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  Novel therapeutics in breast, pancreatic and colorectal cancers

   Cardiff School of Biosciences

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  Dr R Clarkson, Prof A Westwell, Dr A Brancale  Applications accepted all year round  Self-Funded PhD Students Only

About the Project

The host laboratories based in the European Cancer Stem Cell Research Institute, School of Biosciences and the School of Pharmaceutical Sciences, University of Cardiff have developed two novel classes of therapeutic agent for oncology that target two distinct cancer cell pathways: Bcl-3 which plays a role in cancer stem cell maintenance, cell migration (leading to metastasis, the primary cause of cancer patient deaths) and DNA damage repair; and cFLIP, which is involved in TRAIL mediated apoptosis leading to cancer stem cell specific killing primarily mediated through tumour immuno-surveillance. The two classes of small molecule inhibitors developed within the lab are at different stages in the translational pipeline towards clinical trails. Bcl3 inhibitors are in an advanced stage where future studies will aid in confirming the mechanism of action and identification of molecular biomarkers of response to the agents in cell and animal models of cancer to instruct impending clinical trials. cFLIP inhibitors are at an earlier stage where further evaluation of potent analogues is required alongside the elucidation of the types of cancer that would most benefit from their use. PhD projects are available in both of these research areas - hosted by the Clarkson laboratory. We are seeking self-funded students in the first instance with the prospect of industry sourced funding for one or both projects in the near future, so we would welcome initial/preliminary enquiries from potential students with excellent academic track records and/or experience in research laboratory environments, who have not yet secured their own funding.

Candidate requirements

A 1st or Upper 2nd class UK honours degree or equivalent. Please visit School of Biosciences Postgraduate Research for more details.

For those whose first language is not English, IELTS with an overall score of 6.5 with 5.5 in all subskills, or equivalent. Please see our English Language Requirements guidance for more details.

How to Apply 

To submit a formal application via Cardiff University’s online application service, click the 'Institution Website' button on this advert; in the ‘Apply’ box at the top-right of the page, select Qualification (Doctor of Philosophy), Mode of Study (Full Time) and Start Date (this can be flexible as it is a self-funded project). This will take you to the application portal.

Candidates must submit the following:

 • Supporting statement

 • CV

 • Qualification certificates

 • Proof of English language (if applicable) 

In the research proposal section of the application, specify the project title and supervisors of the project. In the funding section, specify that you will be self-funding. If you are applying for more than one Cardiff University project with the same entry intake, please note this in the research proposal section as the form only allows you to enter one title.

Biological Sciences (4) Medicine (26)

Funding Notes

There is no funding attached to this project, so students will need to source their own (tuition, bench fees if applicable, living fees if applicable).

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