This is one of several projects available on an MRC funded 4-year multi-disciplinary PhD programme in Human Genetics, Genomics and Disease at the MRC Human Genetics Unit (HGU), part of the Institute of Genetics and Molecular Medicine (IGMM) at the University of Edinburgh.
Cellular senescence permanently arrests proliferation in cells with persistent DNA damage. Cellular senescence contributes to organismal ageing. A striking feature of cellular senescence is a dramatic nuclear chromatin reorganization, with loss of heterochromatin away from the nuclear periphery and the appearance of internal senescence-associated heterochromatin foci (SAHF). This project will use a combination of super-resolution imaging, molecular and cell biology approaches to investigate the role of nuclear pores in driving heterochromatin away from the nuclear periphery during senescence and the influence that this has on the gene expression of senescent cells.