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Nuclear pores, heterochromatin organisation and cellular senescence

  • Full or part time
  • Application Deadline
    Friday, April 19, 2019
  • Competition Funded PhD Project (European/UK Students Only)
    Competition Funded PhD Project (European/UK Students Only)

Project Description

This is one of several projects available on an MRC funded 4-year multi-disciplinary PhD programme in Human Genetics, Genomics and Disease at the MRC Human Genetics Unit (HGU), part of the Institute of Genetics and Molecular Medicine (IGMM) at the University of Edinburgh.

Project details:

Cellular senescence permanently arrests proliferation in cells with persistent DNA damage. Cellular senescence contributes to organismal ageing. A striking feature of cellular senescence is a dramatic nuclear chromatin reorganization, with loss of heterochromatin away from the nuclear periphery and the appearance of internal senescence-associated heterochromatin foci (SAHF). This project will use a combination of super-resolution imaging, molecular and cell biology approaches to investigate the role of nuclear pores in driving heterochromatin away from the nuclear periphery during senescence and the influence that this has on the gene expression of senescent cells.

For further information on how to apply for this project, please visit: https://www.ed.ac.uk/mrc-human-genetics-unit/graduate-research-and-training/mrc-four-year-phd-programme-human-genetics

Funding Notes

For full funding (fees and stipend) students must be UK or EU citizens who have been resident in the UK for 3 years prior to commencement.

However, EU students with quantitative or multidisciplinary skills are eligible for full funding.

Related Subjects

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