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Nuclease-resistant DNA nanostructures for high precision plant genome engineering

Project Description

The recent development of targeted modification of plant genomes heralds a new era in biotechnology for the 21st century. This project will develop new approaches for plant genome engineering based on nanotechnology to design DNA structures that promote genome integration at a targeted site. This technology will be combined with CRISPR-Cas9 nucleases, a biotechnology tool that is revolutionizing modern biology and medicine. The application of nanotechnology to CRISPR-Cas9 mediated gene targeting has the promise of high throughput precision engineering of the plant genome, key to the development of synthetic biology and the new generation of crop plants. These biotechnological approaches will be essential if we are to meet the demand required by the growing world population for sustainable increased food and energy production against the challenges of climate change, limited land for cultivation and increased pressure on natural resources.

Funding Notes

White Rose BBSRC Doctoral Training Partnership in Mechanistic Biology
4 year fully-funded programme of integrated research and skills training, starting Oct 2019:
• Research Council Stipend
• UK/EU Tuition Fees
• Conference allowance
• Research Costs

At least a 2:1 honours degree or equivalent. We welcome students with backgrounds in biological, chemical or physical sciences, or mathematical backgrounds with an interest in biological questions.
EU candidates require 3 years of UK residency in order to receive full studentship

Not all projects advertised will be funded; the DTP will appoint a limited number of candidates via a competitive process.

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How good is research at University of Leeds in Biological Sciences?

FTE Category A staff submitted: 60.90

Research output data provided by the Research Excellence Framework (REF)

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