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Nucleic Acid Remodeling by Cold Shock Proteins

Project Description

Within the framework of a collaborative project between the University of Zürich and University of Leipzig, we have an open PhD position to fill immediately. The candidate for this biophysics project will dissect the mechanisms of nucleic acid recognition and unwinding by a class of proteins termed Cold Shock Proteins (Csps). The project will be based primarily on correlated measurements involving single molecule fluorescence and nanomechanical experiments (magnetic tweezers). We are also particularly interested in dissecting and modeling the ligand-dependent conformational dynamics and transitions of the Csps.

The ideal candidate will have a masters degree in physics, physical chemistry or quantitative biochemistry with strong interest in molecular biophysics. Interest or expertise in programming is not required but considered an advantage. Prior experience with handling of biomolecules is a plus.

This research will be conducted in the molecular biophysics lab (chaired by Prof. Ralf Seidel) at the University of Leipzig. We work in close collaboration with Dean Prof. Dr. Roger Stefan from the University of Zurich.

Applications will be considered on a rolling basis (in the order in which they are received).

Funding Notes

Funding is available.

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