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Nucleotides bearing polar or charged functional groups for enzymatic synthesis of modified DNA

  • Full or part time
    Prof M Hocek
  • Application Deadline
    Sunday, February 23, 2020
  • Competition Funded PhD Project (Students Worldwide)
    Competition Funded PhD Project (Students Worldwide)

Project Description

New nucleosides and nucleoside triphosphates bearing polar or charged functional groups (e.g. acidic or basic groups, cationic or anionic substituents, etc.) will be designed and synthesized. The modified dNTPs will be studied as substrates for DNA polymerases and as building blocks for enzymatic synthesis of modified or hypermodified DNA bearing different combinations of functional groups in the major groove. These nucleic acids will be used for the selection of aptamers.

How to apply

To apply for a PhD study at IOCB Prague, you must hold a Master’s degree (MSc) or the equivalent of the MSc in similar field (four or five year undergraduate degree). The application can be submitted before obtaining the Master’s degree, however, the applicant should obtain the degree within five months after the application deadline.

For more information visit our website “Call for PhD applications 2020”:
https://www.uochb.cz/en/phd-program

If you decided to apply, please do so online via our application form:
https://www.uochb.cz/en/call-for-phd-applications

Funding Notes

Regular monthly income of students at IOCB Prague varies depending on the faculty scholarship and supervisor's financial options.

References

Hocek, M.: "Enzymatic Synthesis of Base-Functionalized Nucleic Acids for Sensing, Cross-linking, and Modulation of Protein–DNA Binding and Transcription" Acc. Chem. Res. 2019, 52, 1730-1737.

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