New nucleosides and nucleoside triphosphates bearing polar or charged functional groups (e.g. acidic or basic groups, cationic or anionic substituents, etc.) will be designed and synthesized. The modified dNTPs will be studied as substrates for DNA polymerases and as building blocks for enzymatic synthesis of modified or hypermodified DNA bearing different combinations of functional groups in the major groove. These nucleic acids will be used for the selection of aptamers.
How to apply
To apply for a PhD study at IOCB Prague, you must hold a Master’s degree (MSc) or the equivalent of the MSc in similar field (four or five year undergraduate degree). The application can be submitted before obtaining the Master’s degree, however, the applicant should obtain the degree within five months after the application deadline.
For more information visit our website “Call for PhD applications 2020”: https://www.uochb.cz/en/phd-program
If you decided to apply, please do so online via our application form: https://www.uochb.cz/en/call-for-phd-applications
Hocek, M.: "Enzymatic Synthesis of Base-Functionalized Nucleic Acids for Sensing, Cross-linking, and Modulation of Protein–DNA Binding and Transcription" Acc. Chem. Res. 2019, 52, 1730-1737.