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  Nucleotides bearing reactive groups for immobilization of oligonucleotides or for bioconjugations


   Organic Chemistry

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  Prof M Hocek  No more applications being accepted  Competition Funded PhD Project (Students Worldwide)

About the Project

Novel base-modified nucleoside triphosphates bearing reactive groups will be prepared and their polymerase catalyzed incorporation to oligoribonucleotides and DNA or RNA will be studied. The base-modifications will include reactive functional groups for immobilization of oligonucleotides to solid surfaces and for bioconjugations with other biomolecules.

How to apply
To apply for a PhD study at IOCB Prague, you must hold a Master’s degree (MSc) or the equivalent of the MSc in similar field (four or five year undergraduate degree). The application can be submitted before obtaining the Master’s degree, however, the applicant should obtain the degree within five months after the application deadline.

For more information visit our website “Call for PhD applications 2019”:
https://www.uochb.cz/web/structure/797.html

You can apply online via our application form http://www.uochb.cz/phdapplication/index.php/PhDrecruitment

Enquiries
All general enquiries should be directed to Katerina Solcova ([Email Address Removed]). Scientific enquiries can be addressed to the supervisor ([Email Address Removed]).

Funding Notes

Regular monthly income of students at IOCB Prague varies depending on the faculty scholarship and supervisor's financial options.

References

1. Dadová, J.; Orság, P.; Pohl, R.; Brázdová, M.; Fojta, M.; Hocek, M. "Vinylsulfonamide and acrylamide modification of DNA for cross-linking with proteins" Angew. Chem. Int. Ed. 2013, 52, 10515-10518.
2. Olszewska, A.; Pohl, R.; Brázdová, M.; Fojta, M.; Hocek, M. "Chloroacetamide-linked nucleotides and DNA for cross-linking with peptides and proteins" Bioconjug. Chem. 2016, 27, 2089–2094.