About the Project
This project will explore issues related to ocular staining with lissamine green. Although this staining agent has been used for many years in clinical ophthalmic practice, relatively little is known about its precise interaction with the ocular surface and an improved understanding in this area would improve clinical management and patient care.
The work will initially review current understanding of lissamine green staining via a literature view. Then, a series of clinical projects will be conducted to evaluate staining of the ocular surface and lid margins and how this changes diurnally both in contact lens wearers and non-wearers. The recovery from staining will also be assessed.
A project to identify the biological underpinnings of Lissamine Green staining will also be conducted. This work will involve impression cytology of the bulbar and lid margin conjunctiva and determining the nature of the removed cells using a range of cell biology techniques
Training/techniques to be provided
Training will be offered in: critical analysis of the literature, clinical study design, data analysis, oral and presentation skills, clinical and laboratory techniques.
Entry requirements
Candidates are expected to hold (or be about to obtain) a minimum upper second class honours degree (or equivalent) in optometry or a related subject area. The work would especially suit a GOC-registered optometrist and someone with experience in cell biology laboratory techniques.
Before you Apply
Applicants must make direct contact with preferred supervisors before applying. It is your responsibility to make arrangements to meet with potential supervisors, prior to submitting a formal online application.
How To Apply
For information on how to apply for this project, please visit the Faculty of Biology, Medicine and Health Doctoral Academy website (https://www.bmh.manchester.ac.uk/study/research/apply/). Informal enquiries may be made directly to the primary supervisor. On the online application form select PhD Optometry.
For international students, we also offer a unique 4 year PhD programme that gives you the opportunity to undertake an accredited Teaching Certificate whilst carrying out an independent research project across a range of biological, medical and health sciences. For more information please visit https://www.bmh.manchester.ac.uk/study/research/programmes/integrated-teaching/
Your application form must be accompanied by a number of supporting documents by the advertised deadlines. Without all the required documents submitted at the time of application, your application will not be processed and we cannot accept responsibility for late or missed deadlines. Incomplete applications will not be considered.
If you have any queries regarding making an application please contact our admissions team FBMH.doctoralacademy.admissions@manchester.ac.uk.
Equality, Diversity and Inclusion
Equality, diversity and inclusion is fundamental to the success of The University of Manchester, and is at the heart of all of our activities. The full Equality, diversity and inclusion statement can be found on the website https://www.bmh.manchester.ac.uk/study/research/apply/equality-diversity-inclusion/
Funding Notes
References
Efron N., Brennan N.A., Morgan P.B., Wilson T. Lid wiper epitheliopathy (2016) Progress in Retinal and Eye Research, 53, pp. 140 – 174 DOI: 10.1016/j.preteyeres.2016.04.004
Khan T.F., Price B.L., Morgan P.B., Maldonado-Codina C., Dobson C.B. Cellular fluorescein hyperfluorescence is dynamin-dependent and increased by Tetronic 1107 treatment (2018) International Journal of Biochemistry and Cell Biology, 101, pp. 54 – 63 DOI: 10.1016/j.biocel.2018.05.01
Bakkar M.M., Hardaker L., March P., Morgan P.B., Maldonado-Codina C., Dobson C.B. The cellular basis for biocide-induced fluorescein hyperfluorescence in mammalian cell culture (2014) PLoS ONE, 9 (1), art. no. e84427 DOI: 10.1371/journal.pone.0084427
Navascues-Cornago M., Morgan P.B., Maldonado-Codina C. Lid margin sensitivity and staining in contact lens wear versus no lens wear (2015) Cornea, 34 (7), pp. 808 – 816 DOI: 10.1097/ICO.0000000000000448
Open Days
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