Ontogeny and developmental functions of “layered” immune cells
• Background: Immune development occurs in distinct waves starting early in embryogenesis. This generates a "layered" immune system, in which some lineages have different origins throughout life, but may retain embryo-derived cells into adulthood. We hypothesize that (1) embryonic immune cells play important roles in development and (2) embryo-derived cells may exert non-redundant functions at defined developmental stages or in adult conditions biologically resembling development.
• About the Project: This project aims to (1) further delineate the developmental kinetics of macrophages and mast cells and (2) address their functions in conditions where embryo-derived cells either predominate or co-exist with adult cells. To do so, the student will primarily use in vivo mouse models.
• About the lab: The newly established Gentek lab (https://www.ed.ac.uk/inflammation-research/people/principal-investigators/dr-rebecca-gentek) is located in the University of Edinburgh Centre for Inflammation Research, which is part of the Institute for Regeneration and Repair located on the Edinburgh BioQuarter campus and offers excellent state-of-the-art research facilities and a highly collaborative and interdisciplinary research environment with extensive scientific exchange.
The successful applicant will be awarded a 3 year studentship, which includes their stipend and tuition fees (at the UK/EU rate), and contributions towards travel and research costs for their PhD project.
The studentship will be awarded competitively. Applicants should hold at least an upper second class degree or equivalent in a relevant discipline (e.g. immunology or developmental biology). Applicants should submit the following documents [Email Address Removed] : (i) Personal statement about their research interests and their reasons for applying; and (ii) CV.
Applicants should also arrange for two academic referees to submit letters of reference via email before the deadline. All documents should be submitted no later than 5pm on Thursday 30 April 2020. Short-listed candidates will be notified by email.
Informal enquiries can be sent via email to [email protected]