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Optimising Drug Delivery to Targets within the Spleen by Understanding the Relationship Between Drug Structure and Drug Disposition

  • Full or part time
  • Application Deadline
    Thursday, April 04, 2019
  • Competition Funded PhD Project (European/UK Students Only)
    Competition Funded PhD Project (European/UK Students Only)

Project Description

The spleen is a key target organ for immunotherapy as it contains a high concentration of lymphocytes and macrophages. Drug interaction with these two cell types may have implications both in terms of therapeutic or toxic activity and in terms of drug disposition. Little is known about the possible involvement of macrophages and lymphocytes in drug metabolism and there may be implications for how drugs are distributed within the spleen and whether they can reach their molecular target. The expression of major drug metabolising enzymes and drug transporters in the spleen will be determined and their effect on drug disposition will be determined using mass spectrometry and kinetic analysis. The project proposal involves a multidisciplinary approach ranging from cellular sciences to analytical chemistry to kinetic modelling and will provide an excellent training potential for a researcher with an interest in applied pharmacology and the pharmaceutical industry.

Informal enquiries should be directed to Dr Stuart Paine. Email: Studentship comes with an enhanced stipend over 4 years To be considered for the studentship, please send the following documents: • A detailed CV; • Names and addresses of two referees; • A covering letter highlighting your research experience/capabilities; • Copies of your degree certificates with transcripts; • Evidence of your proficiency in the English language, if applicable.

Funding Notes

iCASE studentships are 4-year PhD projects, which include full fees and stipend (for UK students - EU students are eligible for fees only. International students are not eligible to apply for iCASE studentships). The standard stipend rate for 2019/20 will be £15,009, but some studentships may be subject to an enhanced stipend (see individual listings for details).

References

BBDTP-ICase-SP

How good is research at University of Nottingham in Agriculture, Veterinary and Food Science?

FTE Category A staff submitted: 111.45

Research output data provided by the Research Excellence Framework (REF)

Click here to see the results for all UK universities

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