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Optimising host response biology to advance wound dressing efficacy

   Doctoral College

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  Dr S Sandeman, Prof Cyril Crua, Dr D Sarker  No more applications being accepted  Funded PhD Project (UK Students Only)

About the Project

Chronic, non-healing wounds affect 22 million patients annually. Whilst advances have been made in antimicrobial and moisture protecting dressings there remaining significant challenges in providing dressings which can resolve chronic inflammation within the non-healing wound bed. One of the most important considerations is optimisation of the interface between the dressing and the wound bed in order to moderate hyper-inflammation and promote wound healing. This can be done through biomimicry in which host response biology is taken into account to improve protein interactions, prevent biofouling and other negative triggers which repress wound resolution. The aim of this study is therefore to profile and optimise wound resolution processes using dressings modified with biomimetic macromolecules for improved tissue integration and healing.   

In the first part of the study a profile of the wound bed environment will be created using wound dressing exudate (Sandeman, Crua). The interaction and penetration of protein, cells and fluid within wound dressing materials will be considered (Sandeman, Crua, Sarker). Surface modification with biomimetic macromolecules and their impact on these interactions will then be investigated in order to optimise biointerfacial phenomena, improve dressing biocompatibility, efficacy and promote wound healing (Sandeman, Crua, Sarker). 

Funding Notes

Due to the post’s funding, it is only open to home applicants as defined by the Fees Regulations. Funded by the University of Brighton and supports the EPSRC Healthcare Technologies grant. Applications are welcomed from candidates considering a full-time or part-time mode of study. For students meeting the Home fee requirements, the studentship consists of full UK tuition fees as well as a Doctoral Stipend at the UKRI rate. For full-time study the studentship is for 3 years, for part-time student, the studentship is for 6 years, with the stipend being 50% of the UKRI rate.
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