Chronic, non-healing wounds affect 22 million patients annually. Whilst advances have been made in antimicrobial and moisture protecting dressings there remaining significant challenges in providing dressings which can resolve chronic inflammation within the non-healing wound bed. One of the most important considerations is optimisation of the interface between the dressing and the wound bed in order to moderate hyper-inflammation and promote wound healing. This can be done through biomimicry in which host response biology is taken into account to improve protein interactions, prevent biofouling and other negative triggers which repress wound resolution. The aim of this study is therefore to profile and optimise wound resolution processes using dressings modified with biomimetic macromolecules for improved tissue integration and healing.
In the first part of the study a profile of the wound bed environment will be created using wound dressing exudate (Sandeman, Crua). The interaction and penetration of protein, cells and fluid within wound dressing materials will be considered (Sandeman, Crua, Sarker). Surface modification with biomimetic macromolecules and their impact on these interactions will then be investigated in order to optimise biointerfacial phenomena, improve dressing biocompatibility, efficacy and promote wound healing (Sandeman, Crua, Sarker).