Are you applying to universities? | SHARE YOUR EXPERIENCE Are you applying to universities? | SHARE YOUR EXPERIENCE

Optogenetic control of chronic epilepsy, using brain-machine interfaces. (Neuroscience)

   Biosciences Institute

This project is no longer listed on and may not be available.

Click here to search for PhD studentship opportunities
  Dr F Lebeau, Dr A Jackson, Prof A Trevelyan  No more applications being accepted  Competition Funded PhD Project (Students Worldwide)

About the Project

Epilepsy is common, and while many people with the condition are helped by anti-epileptic medication, around a third continue to experience many seizures. With these difficult “medically-refractory” cases, new technologies may yet help; one such approach is the use of optogenetic techniques and brain-machine-interfaces to control neuronal activity. This project builds upon the CANDO project (, which aimed to combine gene therapy and optoelectronic implants to control seizure activity using optogenetics. We were able to control cortical network activity using light, but there are still many important questions to answer, such as which opsin and what form of feedback control to use for different types of epilepsy, and how is this affected by the sleep-wake cycle.

This studentship will provide training in a range of rodent in vitro and in vivo models of seizure activity, and will also study activity patterns in human brain tissue resected for treatment of intractable epilepsy. Overall, this is a novel and exciting project that will provide an excellent opportunity for the student to develop a range of technical and computational skills, as well as knowledge about the causes and treatment of epilepsy.

How to Apply:

Applications should be made by emailing [Email Address Removed] with:

  • a CV (including contact details of at least two academic (or other relevant) referees);
  • A covering letter – clearly stating your first-choice project, and optionally 2nd and 3rd ranked projects, as well as including whatever additional information you feel is pertinent to your application; you may wish to indicate, for example, why you are particularly interested in the selected project(s);
  • copies of your relevant undergraduate degree transcripts and certificates;
  • a copy of your passport (photo page).

A GUIDE TO THE FORMAT REQUIRED FOR THE APPLICATION DOCUMENTS IS AVAILABLE AT . Applications not meeting these criteria may be rejected.

In addition to the above items, please email a completed copy of the Application Form (as a Word document) to [Email Address Removed]  A blank copy of this form can be found at:

Informal enquiries may be made to [Email Address Removed]. The closing date for applications is 31st March 2022 at 5.00pm (UK time).

Funding Notes

PhD studentships are funded by Epilepsy Research UK (ERUK) for 3 years. Funding will cover tuition fees at the UK rate only, a Research Training and Support Grant and stipend (£15,609, 2021/22 rate). Applications are welcomed from students in all countries, although students from outside the UK will be required to pay full international fees. International students may be eligible for financial support to cover some or all of these fees.


Zaaimi et al (2021) Closed-loop optogenetic control of normal and pathological network dynamics. DOI:10.21203/
Graham et al (2021)
Search Suggestions
Search suggestions

Based on your current searches we recommend the following search filters.

PhD saved successfully
View saved PhDs