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Oral microflora in patients with Type 2 diabetes and their response to oral formulations targeting periodontal complications


Project Description

This exciting PhD opportunity is in partnership with the American worldwide consumer product company Colgate-Palmolive, in an emerging R&D area of developing oral formulations for individuals with diabetes.

The project focusses on analysis of volatile markers from the mouths of patients with Type 2 diabetes. One of the most common chronic diseases worldwide, diabetes is now an increasing health issue in the developing world. In West Africa (excluding the northern sub-Sahara) 16 million people have been diagnosed with Type 2 diabetes. This part of Africa will see the largest increase in diabetes in the world in the next 20 years.

Periodontal disease affecting the gum and bone supporting the teeth is a significant complication that can affect patients with diabetes. It is estimated that 1 in 3 diabetics suffer from periodontitis. This is considered the 6th complication of diabetes, along with neuropathy, nephropathy, retinopathy, and micro- and macrovascular diseases. This study will provide baseline information on the oral microbiome of healthy and Type 2 diabetic patients with Caucasian and African origin. This will help tailor adequate oral formulations for various clinical and ethnic groups to best control periodontal disease associated with diabetes.

The project involves:

1. The use of an in vitro perfusion biofilm system based on known periodontal pathogens, and;
2. analysing their volatile organic (VOC) profile by Selected ion flow tube mass spectrometry (SIFT-MS) and by the use of an electronic device the NeOse (http://neosepro.com).
3. Microbial samples will be then taken from the gingiva of healthy volunteers and diabetic patients recruited from both Bristol, UK (including deprived working-class areas), and urban and rural parts of Nigeria, and analysed in our in vitro model system.
4. VOC analysis with SIFT-MS and NeOse will be carried out and their response to different oral formulations under development will be monitored.
5. The bacterial profile will also be analysed by Human Oral Microbe Identification Microarray (HOMIM) and bioinformatics.
6. Oral formulations with the most advantageous properties will be used in our clinical trials in the UK and Nigeria to monitor VOC production using the NeOse. This research will help shape up the creation of new oral formulations to control periodontal disease in diabetics.

Eligibility

Minimum of a good honours degree (2:1) in a relevant scientific discipline (e.g. Biological or Biomedical Sciences with substantial microbiology training.)

A recognised English language qualification is required.

We are looking for a self-motivated researcher with strong organisational, technical and analytical skills and a local knowledge of Nigeria, to address the overall aims of the project in an innovative manner.

For further details, including how to apply:

https://www1.uwe.ac.uk/research/postgraduateresearchstudy/studentshipopportunities/oralmicroflorastudentship.aspx

For an informal discussion, please email Dr Saliha Saad , or Professor Aniko Varadi .

Funding Notes

The studentship will start on 01/10/2019, and consists of an annual tax-free stipend of £15,009 for three years, and full-time Home/EU tuition fees for the length of the funding period, both subject to satisfactory progress.

All applicants will be considered for the full funding offer, regardless of fee status.

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