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Orthogonal translation of unnatural polymers

  • Full or part time
    Dr J Chin
  • Application Deadline
    Tuesday, December 03, 2019
  • Competition Funded PhD Project (Students Worldwide)
    Competition Funded PhD Project (Students Worldwide)

Project Description

The aim of this project is to develop foundational technologies to convert the cellular protein synthesis machinery into a factory for the synthesis of unnatural polymers. The project will involve engineering cells, and evolving key cellular systems for unnatural polymer synthesis.

Funding Notes

Please see the LMB PhD website for further details: View Website

References

Expanding and Reprogamming the Genetic Code. J. W. Chin. Nature 2017 550: 53-60

Defining Synonymous Codon Compression Schemes by Genome Recoding. K. Wang, J. Fredens, S. F. Brunner, S. H. Kim, T. Chia, J. W. Chin. Nature 2016 539:59-64

Ribosome subunit stapling for orthogonal translation in E. coli. Fried S, Schmied W, Uttamapinnant C, Chin JW.
Angew Chem
DOI: 10.1002/anie.201506311

Optimized orthogonal translation of unnatural amino acids enables spontaneous protein double-labelling and FRET.
Wang K, Sachdeva A, Cox DJ, Wilf NM, Lang K, Wallace S, Mehl RA, Chin JW.
Nat Chem. 2014 May;6(5):393-403.

Encoding multiple unnatural amino acids via evolution of a quadruplet-decoding ribosome.
Neumann H, Wang K, Davis L, Garcia-Alai M, Chin JW.
Nature. 2010 Mar 18;464(7287):441-4.

Evolved orthogonal ribosomes enhance the efficiency of synthetic genetic code expansion.
Wang K, Neumann H, Peak-Chew SY, Chin JW.
Nat Biotechnol. 2007 Jul;25(7):770-7.

A network of orthogonal ribosome x mRNA pairs.
Rackham O, Chin JW.
Nat Chem Biol. 2005 Aug;1(3):159-66.

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