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Project Description

Project description:
For this studentship, the successful candidate will join a multidisciplinary research team at the Centre for Movement, Occupational and Rehabilitation Sciences (MOReS) working on a pioneering new University of Oxford study, “OxSOCRATES”, that addresses the origins of cardiovascular disease in the young and, in particular, how sedentary behaviour and obesity contribute to early disease development. The study is funded by the British Heart Foundation and will use advanced MRI, echocardiography, blood tests and a meal-challenge to comprehensively characterise how early metabolic dysfunction (liver and muscle fat, insulin resistance) affects cardiovascular health (arterial stiffness, myocardial energetics, gut vasoreactivity, diastolic function, blood pressure trajectory, left ventricular hypertrophy) in 210 adolescents. Reversibility of this phenotype will be tested in the obese by randomised controlled trial of an exercise program. The study is led by Dr. Alexander Jones (Paediatric Cardiologist and Senior Clinical Scientist, Department of Paediatrics, University of Oxford), who brings expertise in the early cardiometabolic abnormalities of childhood that precede established adult cardiovascular disease, and works in close collaboration with Professor Helen Dawes (Director of MOReS, Faculty of Health and Life Sciences, Oxford Brookes University), who brings a wealth of expertise from her studies of children’s exercise physiology in the Oxfordshire region. The successful candidate will:
• support the assessment of the adolescents in the clinical setting
• be trained in MRI, ultrasound techniques etc. (training will be offered)
• be trained in cannulation and handling of blood samples
• engage with and visit participating schools
• provide an exercise intervention and ongoing support to participating schools
• participate fully in relevant research activities
• present at relevant scientific meetings and to publish their work

Appropriate training relevant to undertaking a PhD will be provided as well as an honorary contract with Oxford University Hospitals NHS Foundation Trust
Any successful candidate will be subject to a DBS search once they enrol. In view of checking procedures they will be required to exhibit specified documents:
For further information on the project please e-mail Prof. Helen Dawes or Dr Alexander Jones

Funding Notes

Eligibility: Home/EU Students
Bursary: £15,009
Fees: Tuition fees will be paid for by the University
Start date: September 2019

Applicant must hold a UK/EU passport and a degree in a discipline related to the expectations of the role.

For how to apply (form and guidance):
View Website

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