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Peptidomimetic Inhibitors for the MraY-protein E interaction site as anti-Pseudomonas therapeutics

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  • Full or part time
    Prof T Bugg
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  • Funded PhD Project (Students Worldwide)
    Funded PhD Project (Students Worldwide)

Project Description

PhD in Interdisciplinary Biomedical Research

Fully funded studentship available for entry in September 2019

This Industrial Collaborative Award in Science and Engineering (iCASE) studentship is offered by Warwick’s MRC Funded Doctoral Training Partnership (DTP). This training program involves an exciting one-year MSc in Interdisciplinary Biomedical Research and then a three-year PhD project which is co-supervised by experts from both academia and industry. The student will benefit from a comprehensive training program that offers advanced workshops, career planning, transferable skills training and cohort learning events and conferences with ~ 50 other PhD students.

Title: Peptidomimetic Inhibitors for the MraY-protein E interaction site as anti-Pseudomonas therapeutics

University of Warwick and Industry Supervisors: Prof. Timothy Bugg (University of Warwick) and Dr Andrew Merritt (LifeArc)


Project summary

Peptido-mimetic inhibitors of the MraY-protein E interaction as anti-Pseudomonas therapeutics Many antibiotics target cell wall peptidoglycan biosynthesis in bacteria. However the spread of anti-microbial resistance requires the development of new antibiotics. Translocase 1 (MraY) catalyses the first step in cell wall biosynthesis and interacts with protein E from bacteriophage phiX174. We have found that peptides of general sequence Arg-Trp-x-x-Trp, which block interaction of MraY and protein E, show antimicrobial activity against antibiotic resistant strains of Pseudomonas and other gram-negative pathogens. In this project the student will involve chemical synthesis of new peptido-mimetic analogues, guided by docking studies at LifeArc Ltd, to generate a new class of antibiotics.

Applicants should have experience in chemical synthesis and interests in medicinal chemistry.

Warwick’s MRC DTP Overview

MSc Course (Year One)
A one-year taught MSc in Interdisciplinary Biomedical Research, including taught modules (e.g. frontier techniques and research skills in biomedicine, principles and techniques in molecular biology, advanced microscopy and imaging, molecular modelling and physical biology of the cell) and two 11-week research projects.

PhD Project (Years Two – Four)
A three-year PhD project. Students will be supervised jointly by a Warwick Principal Investigator and an industry partner, and will undertake a minimum of three months’ placement with the industry partner.

If you are interested in joining our dynamic DTP community please apply at www.warwick.ac.uk/fac/sci/med/study/mrcdtp/theprogramme/icase/ by Thursday 14 February 2019.

Interviews will take place on Monday 8 April 2019.

Funding Notes

Funding
Studentships covering full fees, consumables and annual stipend of £17,499 * are available. https://warwick.ac.uk/fac/sci/med/study/mrcdtp/apply/funding/ for full information.

Entry Requirements
A strong first degree (2i or above) or international equivalent in a relevant subject. Please see the website for further information about academic entry and residency requirements.

* to be confirmed.



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