About the Project
Available Ph.D. position
Novel coralline scaffold-based repair of brain damage following injury and disease
Finding means to repair brain damage is one of the major goals in biology and regenerative medicine, as it is a major cause of mortality worldwide. Traumatic brain injury (TBI) causes sever tissue loss which is irreversible due to poor self-recovery in the brain. Unfortunately, current therapeutics offer no effective solution. Our lab has developed a novel approach for treating TBI-induced behavioral and functional deficiencies using engineered scaffolds made of coral skeletons. These scaffolds reduce nervous tissue resistance to regeneration, mainly by perturbing the astrocytic scar, and propel endogenous compensatory mechanisms near the wound. As a result, in implanted animals enhanced neurite outgrowth and synaptogenesis can be observed near the wound borders, in conjunction with reduction in anxiety and increased locomotion, compared to non-implanted animal. This approach is utilized now both for deeper understanding of the basic mechanism of the compensation as well as for commercialization as a new brain damage treatment.
The lab focuses mainly on the following goals:
a. identifying the players in the compensatory mechanism
b. designing scaffolds that further accelerate compensation
b. assessing the capacity of the scaffolds to stimulate compensation in brain disease and aging
Methods used in the lab: Scaffold preparation. Neural cell and tissue cultures. Microscopy and spectroscopy. Immunostaining, Image analysis. Brain injury/transplantation. Behavioral tests.
If you are:
(i) Highly innovative
(ii) Original in your thinking!
(iii) And, wish to contribute significantly to the fields of neuroscience and regenerative medicine
Prof. Danny Baranes,
Dept. of Molecular Biology, Ariel University, Israel
Phone: +972-54-323-1608; Email: email@example.com
Accepted students will earn 4 years of scholarship.
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