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Natural products have emerged as a key standard in novel and safe delivery of anticancer bioactive compounds. Apart from their ease of administration and delivery, natural/phytochemicals still face several hurdles, due to their physiochemical and pharmacokinetic properties. Nowadays, nanotechnology has been widely proposed to deliver herbal drugs, due to its drug delivery system which might potentiate the pharmacological profile of phytochemicals. In the last decade, several studies have been focused on targeting synthetic drugs using polymers.
Several research groups reported the semi-synthetic derivative of natural products with polymers, however, there is a need for research to be done with isolated natural compounds. Polymeric conjugation/encapsulation with poor-bioavailable phytopharmaceuticals might increase their bioavailability and thereby may decrease the dose frequency leading to improved patient compliance. As classical prodrugs, they can accelerate the process of endocytosis to cross the cell membrane and reach their intracellular targets. This is because of their enhanced EPR effect, which can enhance the accumulation of tumour mass. The terminal groups are amenable to specific functionalities and allow molecules to be attached to a phytochemical moiety, resulting in targeted specific, and controlled drug delivery.
With this immense potential and possibilities, the present research work is proposed to overcome the hurdle of natural product delivery using nano formulations. The properties of the nano formulation would be combined with the advantages of nano formulation for targeted delivery of the natural anticancer bioactive compounds.
Formal applications can be submitted via the University of Bradford web site; applicants will need to register an account and select 'Full-time PhD in Pharmacy' as the course, and then specify the project title when prompted.
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