Pharmacology of ion channels in human genetic disorders

The School of Biomedical Sciences invites applications from prospective postgraduate researchers who wish to commence study for a PhD in the academic year 2024/25.

We especially welcome applications that connect to the School's core research areas, which include Membrane Biology, Pharmacology, and Neuroscience.

We are studying the properties of human ion channels, primarily potassium channels, that have altered properties caused by genetic disorders. The PhD research project will explore the use of pharmacological agents in reversing the functional effects of inherited mutations that result in amino acid substitutions in the protein. For example, the use of inhibitors to supress an overactive ion channel in either a cellular or animal model of the disorder. These could form the basis of a stratified treatment.

Within our laboratory, we use functional techniques, including patch clamp electrophysiology and cellular fluorescence, to measure ion channel activity and the effects of mutations and pharmacological agents. We also work with structural biologists and medicinal and computational chemists to identify novel ion channel modulators. We also work with colleagues with expertise in animal models of human genetic disorders, as a means for preclinical testing of potential therapeutics.

Some of our recent research in this area has been published in iScience.

Eligibility

Applicants to research degree programmes should normally have at least a first class or an upper second class British Bachelors Honours degree (or equivalent) in an appropriate discipline.

Applicants whose first language is not English must provide evidence that their English language is sufficient to meet the specific demands of their study. The Faculty of Biological Sciences minimum requirements in IELTS and TOEFL tests are:

• British Council IELTS - score of 6.0 overall, with no element less than 5.5
• TOEFL iBT - overall score of 87 with the listening and reading element no less than 20, writing element no less than 21 and the speaking element no less than 22. 

How to apply

To apply for this project applicants should complete an online application form and attach the following documentation to support their application. 

• a full academic CV
• degree certificate and transcripts of marks
• Evidence that you meet the University's minimum English language requirements (if applicable)
• Evidence of funding

To help us identify that you are applying for this project please ensure you provide the following information on your application form;

• Select PhD in Biological Sciences as your programme of study
• Give the full project title and name the supervisors listed in this advert

For information about the application process please contact the Faculty Admissions Team:

e: [Email Address Removed]