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PhD Candidate in Molecular Immunology: Analysing how The Innate Immune System Responds to Sterile Inflammatory

About This PhD Project

Project Description

How does the innate immune system discriminate between the body's own molecules and microbial ones to ensure an effective immune response against invaders while avoiding self-directed inflammation? What are the molecular mechanisms that suppress unwanted activation of innate immunity? How can we harness sterile inflammation to boost the body's anti-tumor immune response? If you are interested in these fundamental questions, come and strengthen our team as a PhD student in molecular immunology!

What you do

The innate immune system is crucial to protect the body against external threats, such as pathogens. However, sometimes innate immune mechanisms are unintentionally activated by self-derived ligands. Such a sterile inflammatory response occurs in autoinflammatory disorders and autoimmune diseases. It is also a hallmark of the tumor microenvironment, where the type and extend of inflammation impacts anti-tumor immunity and disease outcome. We are using molecular, (bio)chemical and cell-based approaches in our research.

Your workplace

The lab you will be working at is embedded within the Department of Immunohematology & Blood transfusion (IHB), which hosts around two hundred researchers and is one of the largest departments of the LUMC. The department provides ample opportunity for collaborations with students and postdocs and plenty of training opportunities through lecture series, seminars and workshops. The lab closely collaborates with the Cell and Chemical Biology department at the LUMC and several labs in the United Kingdom.

Your career at the LUMC

The LUMC helps you with maintaining and developing your knowledge and expertise. We offer internal courses and in-service training to assist you with your personal development. We also offer services in terms of personal development, mobility and career advice.

What we ask

We are looking for an excellent and ambitious candidate with an MSc degree in Biomedical Sciences or a related field. Experience in molecular biology, immunology and/or cell biology is a must. You should be able to work independently as well as in a multi-disciplinary team. You are enthusiastic, driven, work accurately and have outstanding organizational skills. Excellent verbal and written communication skills in English are essential.

More information

You will be employed on the basis of a 36-hour week. Appointment is for a maximum of four years, to be completed with a doctoral thesis.Your salary is € 2,357 gross per month in the first year, amounting to € 3,020 in the fourth year (scale PhD students, CAO-UMC).
References will be requested. You will be asked to give a presentation.

Contact details

Contact: Annemarthe van der Veen, assistant professor, Department of Cell and Chemical Biology, telephone +31(0)71 526 87 27, email

How to apply

If you are interested in this position, please complete the application form by the 28th of April at the latest:

You may also apply through the website

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