In short
Job number : B.23.MB.EO.71
Closing date: 18-06-2023
The position
Would you like to be part of a multidisciplinary research project funded by The European Innovative Council (EIC project: Microvasc) that aims at finding a solution for brain microvascular disease, a major medical and socio-economic problem? Do you want to utilize your skills and experience in in vivo methods (mouse handling, ultrasound and 2-photon imaging, dissection of tissue and immunostaining) to determine the effects of gene mutations found in cerebrovascular monogenic diseases on blood vessel hemodynamics and to test potential drug candidates? Then we would like to meet you!
As a PhD candidate you will characterize mouse models that recapitulate monogenic vascular diseases and you will study the effects of candidate drugs. The cerebrovascular diseases included here are Hereditary Hemorrhagic Telangiectasia (HHT), Cerebral Autosomal Dominant Arteriopathy with Subcortical Infarcts and Leukoencephalopathy (CADASIL), and Retinal vasculopathy with cerebral leukoencephalopathy and systemic manifestations (RVCL-S). In this project, we will apply novel functional ultrasound localization microscopy modalities developed within the consortium. Associated methods will include electrophysiology, single cell RNA sequencing, immunohistochemistry and biochemistry approaches.
Your profile
- You have obtained your MSc degree in biomedical sciences (or will do so in the short term)
- You have a keen interest in biomedical imaging and experience with genetic mouse models;
- Fluency in English, being pro-active and performance-driven, having a structured and responsible approach and possessing good communication and writing skills are all desirable qualifications;
- You look forward to working in a multidisciplinary and international academic settings.
What we offer
You will be given an employment contract for the production of a PhD thesis for the duration of the program with a maximum of four years. The salary amounts to € 2,789 gross per month in the first year, up to a maximum of € 3,536 in the last year with fulltime employment (scale Pro, CLA UMC).
Working at the LUMC
Dr. Lebrin offers an opportunity to start in a highly motivated and interdisciplinary newly formed team embedded within the Einthoven Laboratory that consists of more than 70 junior and senior researchers that work together in a large variety of research projects. The mission of the Einthoven laboratory is to provide a stimulating and collaborative environment with state-of the art facilities for carrying a broad spectrum of studies in vascular biology and regenerative medicine. Dr. Lebrin has a dual position in Physics for medicine and in LUMC. You will also work closely with physicists that develop innovative ultrasound modalities and with clinicians within the consortium which offers the opportunity to expand one’s horizon network.
More information
A detailed job description can be found at www.lumc.nl / vacancies. You may also contact Dr. Franck Lebrin – PhD, associate professor, department of Internal medicine, email:[Email Address Removed], telephone: +31 (0)71 526 81 45.
How to apply
Please send your email, including your motivation and CV, to [Email Address Removed]. Make sure to do this before 18-06-2023. Clearly state the vacancy number of the position you are applying for. It’s also possible to apply via our online form: https://lumc.recruitee.com/l/en/o/b23mbeo71-phd-kandidaat-in-vasculaire-biologie-en-ultrasound-beeldvorming/c/new
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