DNA encoded chemical libraries offer great promise as new methods of finding leads in medicinal chemistry and chemical biology. This technology allows the easy screening of huge numbers (potentially billions) of chemical compounds against protein targets. Current methods are limited by the range of compatible chemistry and of synthetic sequences for library synthesis meaning that encoded libraries do not always contain compounds with lead-like properties. This project will seek primarily to develop new chemical methodology for the synthesis of DNA encoded libraries biologically small molecules. This methodology will then be used to construct libraries and validate their utility by screening against novel biological targets.
The studentship will provide a wealth of experience in medicinal chemistry design and organic synthesis along with the opportunity to interact with scientists at AstraZeneca actively engaged in lead generation projects. This would be ideal training for someone wishing to pursue a career in medicinal chemistry or chemical biology.
The award is available to UK/EU applicants only. Depending on how you meet the EPSRC’s eligibility criteria, you may be entitled to a full or a partial award.
A Master’s level degree in chemistry is required.
How to apply:
You must apply through the University’s online postgraduate application system. To do this please ‘Create a new account’ (https://bit.ly/2sZohey).
All relevant fields should be completed, but fields marked with a red asterisk in the application portal must to be completed. The following information will help us to process your application. You will need to: •insert the programme code 8100F in the programme of study section •select ‘PhD Chemistry - Chemistry’ as the programme of study •insert the studentship code CASE05 in the studentship/partnership reference field •attach a covering letter and CV. The covering letter must state the title of the studentship, quote reference code CASE05 and state how your interests and experience relate to the project •attach degree transcripts and certificates and, if English is not your first language, a copy of your English language qualifications.
Full UK/EU fees (eligibility criteria applies to EU students) and annual living allowance of £14,777 (at the 2018/19 UKRI rate.) Additional funds for a placement with the industrial sponsor, and research project costs are included.