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PhD in Biomedical Engineering: High-throughput Microfluidic Droplet Sorting for Industrial Applications

College of Science and Engineering

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Prof T Franke No more applications being accepted Competition Funded PhD Project (European/UK Students Only)

About the Project

A graduate studentship leading to the award of a PhD is available to work at the University of Glasgow in the School of Engineering, with Prof. Thomas Franke. The project will be completed in collaboration with our industrial partner and visits to their sites are required.

This project will involve the setup and optimization of high-throughput microfluidic droplet sorting systems, plus the testing of the suitability of such systems (in terms of sorting rate and detection sensitivity) for different industrially relevant applications.

This includes but is not limited to the following tests:

- Determining sensitivity of the sorter using different fluorescence detection methods. For example, one target will be to determine the sensitivity of the sorter, relative to rate of sorting, using a biochemical fluorescence assay.
- Other work will involve the use of commercially available E. coli containing incorporated green fluorescent protein (GFP). The target will be to determine the sensitivity relative to number of cells expressing GFP per droplet.
- Experiments will be performed with two different metabolite producing bacteria strains, where the metabolite can be identified using a fluorescence detection method. The target is to successfully identify and sort best 1 – 5% producers.

Applicants should have a university degree in physics, engineering, biotechnology, chemistry or a related, relevant subject. Specific skills in microfluidics, directed evolution, lab on a chip technology, chemical and kinetic analysis of enzyme mechanisms, proteomics, cell sorting and cytometer technology, integrations and automatization of microfluidics are highly advantageous.

Please direct informal enquiries to [Email Address Removed] .

The University of Glasgow

The University of Glasgow is a global leading institution ranked 67th in the world (QS World University Rankings 2020). With more than 29,000 undergraduate and postgraduate students, we welcome students from more than 140 countries worldwide. As a member of the prestigious Russell Group of leading UK research universities with an annual research income of more than £179m, we are a broad-based, research intensive institution with a global reach.

The School of Engineering

The School of Engineering has an outstanding research reputation. In the latest research assessment (REF 2014), 95% of our research has been judged to be "internationally excellent" or "world-leading", placing us 4th in the UK across all the Engineering disciplines. This latest assessment confirms the University of Glasgow’s position as one of the leading Engineering institutions in the UK.
Our research brings together fundamentals, technologies and applications, and through our research we are tackling global challenges and helping to create the emerging technologies of the 21st Century

Funding Notes

The studentship is supported by the University and an industry partner and it will cover tuition fees and provide a stipend of £15,009 (subject to annual increments) for 3.5 years for home/EU students.

Start date: 6th January, 2020
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