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PhD in Chemistry - A close look at redox signalling from mitochondria using small molecule chemistry

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  • Full or part time
    Prof R Hartley
  • Application Deadline
    No more applications being accepted
  • Competition Funded PhD Project (UK Students Only)
    Competition Funded PhD Project (UK Students Only)

Project Description

We used to believe that the reactive oxygen species (ROS) produced by mitochondria were always damaging. Mitochondria are indeed a major source of ROS. It is also true that oxidative stress greatly contributes to serious health conditions: cancer, cardiovascular disease, heart failure, stroke and neurodegeneration. However, supplementing diet with antioxidants does not seem to help, unless you are deficient in these nutrients. We are beginning to understand that this is because ROS are part of a complex signalling system that ensures healthy functioning of cells. Malfunctioning of this redox signalling network causes the serious health problems. However, we do not yet know how this system works and so cannot correct it when it goes wrong.

We hypothesise that it matters where, when and how ROS are generated. The exact location is critical, right down to which side of which membrane in which organelle. For this reason, we will design and use organic synthesis to make novel small-molecule probes that attach themselves to very specific sites in and around the mitochondria and report the signalling events.

The research will involve molecular design with consideration of reactivity and physicochemical properties, multi-step organic synthesis including the handling of moisture and air-sensitive compounds, chemical characterisation of new compounds (NMR, MS, IR, UV-Vis, fluorescence) and validation of probes in vitro, in isolated mitochondria and in cells.

Eligibility: See EPSRC conditions https://epsrc.ukri.org/skills/students/guidance-on-epsrc-studentships/eligibility/

It is the University of Glasgow’s mission to foster an inclusive climate, which ensures equality in our working, learning, research and teaching environment.

We strongly endorse the principles of Athena SWAN, including a supportive and flexible working environment, with commitment from all levels of the organisation in promoting gender equality.

As an Athena SWAN Bronze Award holder, the School of Chemistry has equality, diversity and inclusion at its heart, and actively supports applications from all sections of society.

More details of the School’s Athena SWAN activities can be found here:

https://www.gla.ac.uk/schools/chemistry/abouttheschool/athenaswan/

How to Apply: Please refer to the following website for details on how to apply:
http://www.gla.ac.uk/research/opportunities/howtoapplyforaresearchdegree/

Funding Notes

Funding is available to cover tuition fees for UK applicants for 3.5 years, as well as paying a stipend at the Research Council rate (estimated £15,009 for Session 2019-20). Normally, to be eligible for a full award a student must have no restrictions on how long they can stay in the UK and have been ordinarily resident in the UK for at least 3 years prior to the start of the studentship (see EPSRC eligibility requirements). Truly exceptional international candidates will also be considered in line with EPSRC limited relaxation of eligibility requirements.



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