AMR is expected to cause 10,000,000 deaths a year by 2050, with an associated $1 trillion global cost. Among multi resistant bacteria Staphylococcus aureus (e.g. MRSA), is deemed as high priority pathogen by the WHO for the development of new antibiotics, due to its ability to cause a significant number of life-threatening hospital and community-acquired infections. It is estimated that up to 80% of S. aureus infections are caused by biofilms- that is a community of cells attached to a substrate (i.e. catheter) or each other, and embedded within a matrix of extracellular substance. Biofilms also pose a therapeutic impediment and are notoriously difficult to treat. With an increasing number of vulnerable people in society, it is imperative to discover new drugs effective against organisms such as S. aureus.
The proposed project aims to develop novel antimicrobial compounds to treat Gram-positive bacterial infections by inhibiting key enzymes in the biosynthesis of lipoteichoic acids (LTA), membrane glycopolymers integral to survival of Gram-positive (S. aureus) and its biofilm formation. The first phase of this project will involve the design and synthesis of novel compounds, including their physiochemical evaluation. The second phase will involve the evaluation of novel compounds in a range of biological screens to assess their antibacterial and anti-biofilm activity.
The multidisciplinary nature of this project represents a great opportunity for the student to obtain valuable training in different aspects of medicinal chemistry.
Academic criteria
Candidates should hold or expect to gain a first class degree or a good 2.1 and/or an appropriate Master’s level qualification (or their equivalent).
Applicants whose first language is not English will be required to demonstrate proficiency in the English language (IELTS 6.5 or equivalent)
English language requirements for postgraduate students - Study - Cardiff University
Supervisor
Dr Michaela Serpi
How to apply
We reserve the right to close applications early should sufficient applications be received. Early application is advised.
To apply please complete an online application, stating your supervisor’s name(s):
https://www.cardiff.ac.uk/study/postgraduate/research/programmes/programme/chemistry
Start date - 4th January 2022
Deadline - 30th November 2021
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