This PhD project will seek to improve the speed, sensitivity and accuracy of a sensor array for detecting biomarkers of liver fibrosis, leading to a better blood test for the condition (https://doi.org/10.1002/adma.201800634
). The project will involve the synthesis of luminescent molecular architectures, testing the molecules created against clinical samples, and analysing the data with statistical pattern recognition tools.
The ideal candidate will hold (or expect to hold) a 1st or upper 2nd class MSc/MChem/BSc or equivalent, be a creative and enthusiastic experimentalist, and have excellent communication and organisational skills. Some experience of multi-step synthetic organic/materials chemistry would be advantageous. The researcher can expect to become an expert in the design, synthesis and characterisation of luminescent sensor materials, the use of spectroscopy to analyse complex mixtures and the application of pattern recognition to chemical sensing (chemometrics).
This research intersects synthetic and analytical chemistry, statistics and clinical medicine and will be carried out in collaboration with engineers at Glasgow University and clinicians in Edinburgh and London.
Deaths from liver disease, in contrast to cancer and heart disease, have increased over the last 30 years, at an estimated £9bn annual cost to the NHS. Liver disease severity, treatment and survival are heavily impacted by the amount of liver scarring (fibrosis) that is caused by the disease. To improve detection and treatment of this liver scarring, we are developing blood tests that can identify the condition at an early stage without recourse to painful and invasive liver biopsy. More information on the ongoing work in the group can be found at: https://www.gla.ac.uk/schools/chemistry/staff/williampeveler/
Interested candidates should email Dr Peveler ([email protected]
) a CV and brief cover letter to express interest.
It is the University of Glasgow’s mission to foster an inclusive climate, which ensures equality in our working, learning, research and teaching environment.
We strongly endorse the principles of Athena SWAN, including a supportive and flexible working environment, with commitment from all levels of the organisation in promoting gender equality.
As an Athena SWAN Bronze Award holder, the School of Chemistry has equality, diversity and inclusion at its heart, and actively supports applications from all sections of society.
More details of the School’s Athena SWAN activities can be found here: https://www.gla.ac.uk/schools/chemistry/abouttheschool/athenaswan/
How to Apply: Please refer to the following website for details on how to apply: http://www.gla.ac.uk/research/opportunities/howtoapplyforaresearchdegree/