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PhD in Dementia Research - Identifying the cell-type specific gene networks operating within the Substantia nigra and their dysfunctions across neurological disease.

  • Full or part time
  • Application Deadline
    Sunday, March 31, 2019
  • Competition Funded PhD Project (European/UK Students Only)
    Competition Funded PhD Project (European/UK Students Only)

Project Description

Our knowledge of individual cell types, let alone their functions and how cell type dysfunction underlies disease, is very incomplete. Increasing molecular data, including genomic, epigenomic and transcriptomic data, about each cell type that makes up a tissue is providing new definitions of cell functions and new insights into how different types of cells work together in health and disease. Understanding which cell types disease initially arises within and how other cell types within the same tissue respond is key to understanding the evolution of a diseased tissue. If each molecular data type provides only limited information, integrating several omics data types will enable us to find new insights on how dysfunctions within and across different cell types causes complex disease. Building on our group’s expertise on single cell approaches and functional genomics data integration, we will use a range of external and internal datasets to build Substantia nigra cell-type-specific gene networks that elucidate functional and regulatory associations between genes. We will exploit these cell-type-specific networks to dissect the cell type-specific genetic components of Parkinson’s Disease and Schizophrenia and test our insights within existing cellular models in our lab.

Funding Notes

The funding for the studentship is provided by the UK Dementia Research Institute at Cardiff. Funding is in competition with 5 projects advertised, and an anticipation to fund 3.
Full UK/EU tuition fees
Doctoral stipend matching UK Research Council National Minimum.
Additional funding is available over the course of the programme and will cover costs such as research consumables and training.

Applicants should possess a minimum of an upper second class Honours degree, master's degree, or equivalent in a relevant subject.
Applicants whose first language is not English are normally expected to meet the minimum University requirements (e.g. 6.5 IELTS)

References

The duration of the PhD will be 3.5 years
In order to be considered you must submit a formal application via Cardiff University’s online application service. (To access the system click 'Apply Online' at the bottom of this advert)
There is a box at the top right of the page labelled ‘Apply’, please ensure you select the correct ‘Qualification’ (Doctor of Philosophy), the correct ‘Mode of Study’ (Full Time) and the correct ‘Start Date’ (October 2019). This will take you to the application portal.
In order to be considered candidates must submit the following information:

• Supporting statement
• CV
• Qualification certificates
• References x 2 (references are optional but will strengthen your application)
• Proof of English language (if applicable)

In the 'Research proposal and Funding' section of your application, please specify the project title and supervisors of the project and copy the project description in the text box provided.
Please select 'No, I am not self-funding my research' when asked whether you are self-funding your research.
In the funding section, please select "I will be applying for a scholarship / grant" and specify that you are applying for advertised funding from UK DRI.

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