About the Project
Background: Optical imaging and microscopies underpin both clinical diagnosis and basic biomedical research, studying disease processes, tissue regeneration and developmental processes. Current systems are very effective for thin samples, but one major challenge in the field involves developing new forms of microscopy that are able to determine the spatial location of signalling molecules or biomarkers of disease deep within tissues - and subsequently determine the resulting changes.
Such an optical microscope could find new applications in understanding disease progression, wound healing, or bone re-growth following trauma.
The Project: We wish to develop a new optical imaging tool to probe deep into hard and soft tissues using Raman spectroscopy. This will allow us to study, in real time, the regeneration of tissue in response to treatments. We will probe much deeper into tissues than previously possible, producing high quality images to non-invasively and quantitatively monitor the dynamics of biological processes at a molecular level, in real time.
Scope: Whilst the scope of the project lies in medical imaging of tissue and bone, the techniques that will be developed would have broader applications in monitoring infectious disease within the body (including e.g. sepsis after surgery). During the PhD, the candidate will be encouraged to explore potential new applications.
Collaboration: The successful candidate will be based in our Biomedical Engineering group, within the School of Engineering in Glasgow, and will work closely with the Research Centre for the Cellular Microenvironment (see https://glasgow.thecemi.org) and the Centre for Extreme Light (http://www.physics.gla.ac.uk/XtremeLight/index.html ) based in the School of Physics. During the PhD, the student will also be encouraged to collaborate with a network of researchers in NUS Singapore and Beijing Institute of Technology, with the opportunity to travel.
Facilities: Within our group, our facilities not only include a wide range of spectroscopic and optical microscopy platforms, but also a range of bioanalytical instrumentation, 3D printing, optical workstations and cell/tissue culture suites.
How to Apply: Please refer to the following website for details on how to apply:
To be eligible for this funding, applicants must have ‘settled status’ in the United Kingdom and must have been ‘ordinarily resident’ for the past three years. EU nationals are generally eligible to receive a fees-only award.
It should be noted that other terms may also apply. For full details about eligibility please visit: View Website
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