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  PhD in single-cell Bioinformatics

   Research Center for Environmental Health

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  Dr A Sacher  Applications accepted all year round

About the Project


The Helmholtz Zentrum München in Munich, Germany, is member of one of the leading research associations in Europe – the Helmholtz Association of German Research Centers. The aim of our research is to proactively detect health risks involving humans and the environment, decoding the mechanisms of pathogenesis and developing concepts for prevention and therapy.

Single-cell technologies have recently gained popularity in biology due to their ability to resolve heterogeneity in cell populations. This has translational impact for example in describing heterogeneities of developmental diseases, cancer or immunology, in particular regarding T-cell heterogeneity during infection processes. Analyzing high-dimensional single-cell data has its own statistical and computational challenges, and standard tools often cannot be applied. The goal of this project is to develop and adapt methods in computational biology to model and analyze transcriptional heterogeneity linked to pathomechanisms and infection.

The project is raised by a collaboration between the Institute of Computational Biology at the Helmholtz Zentrum Munich and the Institute for Medical Microbiology, Immunology and Hygiene at the Technical University of Munich.
Job Description
Implement, develop and extend methods for processing
and analyzing single-cell RNAseq and protein profiles
Develop methods for second level analyses, e. g.
interaction networks, enrichment analyses
Biological interpretation of data
Your Qualifications
PhD/MSc degree in bioinformatics, computer science,
mathematics, physics or equivalent
Background in Machine Learning and/or RNAseq analysis
Interest in biological applications
Passion for science and scientific work
Proficient in written and spoken English
Being comfortable in interacting with colleagues in an
interdisciplinary setting
Our Offer
Working in an innovative, well-equipped and scientifically
stimulating surrounding
Further training opportunities
Initial short-term employment contract for two–three years
with a standard public service salary (TV EntgO Bund EG

The activity involves special knowledge and experience specific to own scientific skills.

The Helmholtz Zentrum München as holder of the Bavarian Advancement of Women Prize and of the Total E-Quality Certificate is striving to increase the overall proportion of women on its staff and thus expressly urges qualified women to apply.

Application documents (motivation letter, CV, certificates, two references) should be submitted as soon as possible as a single PDF file via the online portal:

We are looking forward to receiving your comprehensive online application.

Dr. Anna Sacher Phone: +49(0)89 3187-2926
Helmholtz Zentrum München Deutsches Forschungszentrum für Gesundheit und Umwelt (GmbH)
Institute of Computational Biology
Landstraße 1
85764 München

 About the Project