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PhD in Structural biology/Protein biochemistry – The role of protein amyloid fibrils in disease

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  • Full or part time
    Dr V Morris
  • Application Deadline
    No more applications being accepted
  • Funded PhD Project (Students Worldwide)
    Funded PhD Project (Students Worldwide)

About This PhD Project

Project Description

The Morris lab at the University of Canterbury, New Zealand, is seeking a motivated student to carry out investigations of protein aggregation. We study the structures, interactions and mechanisms of amyloid-forming proteins and their roles in disease including neurodegenerative disease and cancer. Specific projects will aim to understand molecular details of protein interactions in Alzheimer’s disease development or mechanistic details and roles of amyloid-forming tumour suppressors. The project will involve a range of structural and biophysical methods including NMR spectroscopy and electron microscopy.

Person
The position is fully funded and covers course fees plus stipend. Applicants must have a BSc(Hons) or MSc, and a background in biochemistry, structural biology or related disciplines. Ideal candidates will be good communicators and co-workers, have an enquiring mind and willingness to learn, and a demonstrated level of high academic achievement. Experience working with proteins is favourable but not essential. You can also find information about eligibility at these links: https://www.canterbury.ac.nz/postgraduate/phd-and-doctoral-study/ https://www.canterbury.ac.nz/enrol/doctoral/

Please contact me at [Email Address Removed] for more specific details about projects or for more information about a PhD in New Zealand.

Group
We are a young, vibrant and growing group with international connections, and we welcome applicants from different backgrounds. You can find more information on the group at our website www.morris-lab.com or in the references below.

Location
The University of Canterbury is one of New Zealand’s top ranked universities and is situated in the city of Christchurch. The campus has modern and well-equipped facilities, and a supportive and stimulating academic environment. Christchurch is a popular tourist base for it’s easy access to outdoor pursuits, being within near reach of mountains and beaches.

Contact
To apply, email me directly at [Email Address Removed] including:
- A cover letter outlining your background, experience and interests, and possible starting dates
- Full CV
- A copy of your academic transcript including grades
- The names and contact details of 2-3 academic referees

References

Göbl C.*, Morris, V.K.*, van Dam, L.*, Visscher M., Polderman P., Hartlmüller C., de Ruiter H., Hora,M., Birner-Gruenberger, R., Vos H., Reif, B., Madl T. and T. Dansen. (2020) Cysteine oxidation triggers amyloid fibril formation of the tumor suppressor p16INK4A. Redox Biology 28, 101216

Cristóvão, J.S., Morris, V.K., Cardoso, I., Leal, S.S, Martinez, J., Botelho. H.M., Göbl, C., David, R., Kierdorf, K., Alemi, M., Madl, T., Fritz, G., Reif, B., and C.M. Gomes (2018) The neuronal S100B protein is a calcium-tuned suppressor of amyloid-β aggregation. Science Advances 4(6), eaaq1702



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